Comparative Assessment of Miniaturized Screening Approaches for Selection of Polymers for Amorphous Drug Stabilization.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.11.006
Abstract: The present work highlights the use of miniaturized approaches to screen and prioritize development of solid dispersions that provide stabilization of the amorphous drug against crystallization and enhanced dissolution over the crystalline form. The approaches… read more here.
Keywords: stabilization; screening approaches; drug; fasted state ... See more keywords
Screening Approaches for Targeting Ribonucleoprotein Complexes: A New Dimension for Drug Discovery
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DOI: 10.1177/2472555218818065
Abstract: RNA-binding proteins (RBPs) are pleiotropic factors that control the processing and functional compartmentalization of transcripts by binding primarily to mRNA untranslated regions (UTRs). The competitive and/or cooperative interplay between RBPs and an array of coding… read more here.
Keywords: targeting ribonucleoprotein; screening approaches; approaches targeting; rna ... See more keywords
Evaluating screening approaches for hepatocellular carcinoma in a cohort of HCV related cirrhosis patients from the Veteran’s Affairs Health Care System
Sign Up to like & getrecommendations! Published in 2018 at "BMC Medical Research Methodology"
DOI: 10.1186/s12874-017-0458-6
Abstract: BackgroundHepatocellular carcinoma (HCC) has limited treatment options in patients with advanced stage disease and early detection of HCC through surveillance programs is a key component towards reducing mortality. The current practice guidelines recommend that high-risk… read more here.
Keywords: cirrhosis patients; hcc; screening approaches; cohort ... See more keywords
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators
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DOI: 10.1515/hsz-2021-0396
Abstract: Abstract Ubiquitination is a key regulatory mechanism vital for maintenance of cellular homeostasis. Protein degradation is induced by E3 ligases via attachment of ubiquitin chains to substrates. Pharmacological exploitation of this phenomenon via targeted protein… read more here.
Keywords: fragment based; covalent fragment; identification; proteasome ... See more keywords