Identification of Inhibitory Compounds Against Singapore Grouper Iridovirus Infection by Cell Viability-Based Screening Assay and Droplet Digital PCR
Sign Up to like & getrecommendations! Published in 2017 at "Marine Biotechnology"
DOI: 10.1007/s10126-017-9785-1
Abstract: Singapore grouper iridovirus (SGIV) is one of the major causative agents of fish diseases and has caused significant economic losses in the aquaculture industry. There is currently no commercial vaccine or effective antiviral treatment against… read more here.
Keywords: cell viability; infection; viability based; screening assay ... See more keywords
A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia
Sign Up to like & getrecommendations! Published in 2019 at "SLAS Discovery"
DOI: 10.1177/2472555218823531
Abstract: Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome caused by mutations in ribosomal protein genes. Pathogenic mechanisms are poorly understood but involve severely reduced proliferation of erythroid precursors. Because current DBA therapies are ineffective… read more here.
Keywords: screening assay; phenotypic screening; blackfan anemia; diamond blackfan ... See more keywords
Activity-Based Screening Assay for Mono-ADP-Ribosylhydrolases
Sign Up to like & getrecommendations! Published in 2020 at "SLAS Discovery"
DOI: 10.1177/2472555220928911
Abstract: ADP-ribosylation is a post-translational modification involved in the regulation of many vital cellular processes. This posttranslational modification is carried out by ADP-ribosyltransferases converting β-NAD+ into nicotinamide and a protein-linked ADP-ribosyl group or a chain of… read more here.
Keywords: adp ribosylhydrolases; activity based; assay mono; adp ... See more keywords
Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients
Sign Up to like & getrecommendations! Published in 2021 at "Slas Discovery"
DOI: 10.1177/24725552211019405
Abstract: Lung imaging and autopsy reports among COVID-19 patients show elevated lung scarring (fibrosis). Early data from COVID-19 patients as well as previous studies from severe acute respiratory syndrome, Middle East respiratory syndrome, and other respiratory… read more here.
Keywords: covid patients; fibrosis; screening assay; high content ... See more keywords
A comparison of two multiplex-PCR assays for the diagnosis of traveller’s diarrhoea
Sign Up to like & getrecommendations! Published in 2021 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-021-05885-3
Abstract: Background Numerous multiplex-PCR assays are now available in routine diagnostics but their clinical value is controversial if a clear association between clinical symptoms and the detection of a particular pathogen is missing. The objective of… read more here.
Keywords: diagnosis traveller; biofire filmarray; traveller diarrhoea; multiplex pcr ... See more keywords
Identification of genes involved in exoprotein release using a high-throughput exoproteome screening assay in Yersinia entomophaga
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263019
Abstract: Bacterial protein secretion is crucial to the maintenance of viability and pathogenicity. Although many bacterial secretion systems have been identified, the underlying mechanisms regulating their expression are less well explored. Yersinia entomophaga MH96, an entomopathogenic… read more here.
Keywords: screening assay; exoprotein release; yersinia entomophaga; exoproteome screening ... See more keywords
Optimization of Ultrahigh-Throughput Screening Assay for Protein Engineering of d-Allulose 3-Epimerase
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12111547
Abstract: d-Allulose is the corresponding epimer of d-fructose at the C-3 position, which exhibits a similar taste and sweetness to sucrose. As a low-calorie sweetener, d-allulose has broad application prospects in the fields of medicine, food,… read more here.
Keywords: daease; screening assay; allulose epimerase; throughput screening ... See more keywords
A Novel Competitive Binding Screening Assay Reveals Sennoside B as a Potent Natural Product Inhibitor of TNF-α
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9091250
Abstract: Natural products (NPs) have played a significant role in drug discovery for diverse diseases, and numerous attempts have been made to discover promising NP inhibitors of tumor necrosis factor α (TNF-α), a major therapeutic target… read more here.
Keywords: inhibitor; inhibitor tnf; competitive binding; screening assay ... See more keywords
Magnetic Ion Channel Activation (MICA)-Enabled Screening Assay: A Dynamic Platform for Remote Activation of Mechanosensitive Ion Channels
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043364
Abstract: This study reports results of a mechanical platform-based screening assay (MICA) to evaluate the remote activation of mechanosensitive ion channels. Here, we studied ERK pathway activation and the elevation in intracellular Ca2+ levels in response… read more here.
Keywords: screening assay; remote activation; mica; ion channels ... See more keywords
Development of a 96-Well Electrophilic Allergen Screening Assay for Skin Sensitization Using a Measurement Science Approach
Sign Up to like & getrecommendations! Published in 2022 at "Toxics"
DOI: 10.3390/toxics10050257
Abstract: The Electrophilic Allergen Screening Assay (EASA) has emerged as a promising in chemico method to detect the first key event in the adverse outcome pathway (AOP) for skin sensitization. This assay functions by assessing the… read more here.
Keywords: screening assay; electrophilic allergen; measurement science; development ... See more keywords
Clinical Application Evaluation of a Fourth-Generation HIV Antigen Antibody Combination Screening Assay.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2019.190220
Abstract: BACKGROUND Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) are infectious diseases with high mortality. Early diagnosis is crucial. Combining HIV antibody and p24 antigen, the Elecsys HIV combi PT assay is a fourth… read more here.
Keywords: hiv; screening assay; antibody; fourth generation ... See more keywords