Virtual Screening and Biological Evaluation of Natural Products as Novel VPS34 Inhibitors that Modulate Autophagy
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202400580
Abstract: VPS34 is a sole member of class III phosphoinositide 3‐kinase involved in endosomal trafficking and autophagosome formation, making it an interesting target for cancer treatment. Here, we investigated 5,774 natural products using structure‐based virtual screening… read more here.
Keywords: virtual screening; inhibitors modulate; natural products; vps34 inhibitors ... See more keywords
Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc-1 Inhibitors Distinct from Traditional High Throughput Screening.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b00913
Abstract: N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and Alzheimer's disease. One… read more here.
Keywords: focused screening; asc inhibitors; iterative focused; screening biological ... See more keywords
Selective Screening of Biological Thiols by Means of an Unreported Magenta Interaction and Evaluation Using Smartphones
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b00783
Abstract: The determination of biological thiols is considered to be of great interest because of the participation of these molecules in physiological disorders as indicators of their existence and progress, such as Alzheimer’s disease, cancer, and… read more here.
Keywords: means unreported; biological thiols; screening biological; interaction ... See more keywords
Synthesis, screening and biological activity of potent thiosemicarbazone compounds as a tyrosinase inhibitor
Sign Up to like & getrecommendations! Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c9nj02360g
Abstract: Inhibitors are designed based on coordination chemistry and catalytic circle of the tyrosinase, coordination atoms binds to copper and blocks enzyme activity, indicated that thiosemicarbazone species possess good potential as tyrosinase inhibitors. read more here.
Keywords: thiosemicarbazone; biological activity; activity; screening biological ... See more keywords
Miniplatforms for Screening Biological Samples for KRAS and Four Mismatch Repair Proteins as New Tools for Fast Screening for Gastric and Colon Cancers
Sign Up to like & getrecommendations! Published in 2023 at "Journal of The Electrochemical Society"
DOI: 10.1149/1945-7111/acd358
Abstract: Two miniplatforms based on stochastic microsensors designed using Nitrogen (9.3%) and Boron (2.4%) - dopped graphene (NB-DG) modified with frutafit HD and frutafit TEX were designed and validated for the assay of MLH1, MSH2, MSH6,… read more here.
Keywords: msh2 msh6; frutafit tex; frutafit; recorded frutafit ... See more keywords
Virtual Screening and Biological Activity Evaluation of New Potent Inhibitors Targeting Hexokinase-II
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27217555
Abstract: Hexokinase-II (HK-II), the rate-limiting step enzyme in the glycolysis pathway, expresses high levels of cancer cells compared with normal cells. Due to its pivotal role in the different aspects of cancer physiology including cellular proliferation,… read more here.
Keywords: activity evaluation; virtual screening; biological activity; screening biological ... See more keywords