A Novel Automated Framework for QSAR Modeling of Highly Imbalanced Leishmania High-Throughput Screening Data
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c01439
Abstract: In silico prediction of antileishmanial activity using quantitative structure-activity relationship (QSAR) models has been developed on limited and small datasets. Nowadays, the availability of large and diverse high-throughput screening data provides an opportunity to the… read more here.
Keywords: highly imbalanced; consensus; high throughput; model ... See more keywords
Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline.
Sign Up to like & getrecommendations! Published in 2021 at "Nature protocols"
DOI: 10.1038/s41596-021-00596-0
Abstract: The continued improvement of combinatorial CRISPR screening platforms necessitates the development of new computational pipelines for scoring combinatorial screening data. Unlike for single-guide RNA (sgRNA) pooled screening platforms, combinatorial scoring for multiplexed systems is confounded… read more here.
Keywords: crispr; screens orthrus; combinatorial crispr; screening data ... See more keywords
MasterPATH: network analysis of functional genomics screening data
Sign Up to like & getrecommendations! Published in 2020 at "BMC Genomics"
DOI: 10.1186/s12864-020-07047-2
Abstract: Background Functional genomics employs several experimental approaches to investigate gene functions. High-throughput techniques, such as loss-of-function screening and transcriptome profiling, allow to identify lists of genes potentially involved in biological processes of interest (so called… read more here.
Keywords: screening data; genomics screening; functional genomics; network analysis ... See more keywords
Mapping HL7 CDA R2 Formatted Mass Screening Data to OpenEHR Archetypes
Sign Up to like & getrecommendations! Published in 2017 at "Studies in health technology and informatics"
DOI: 10.3233/978-1-61499-830-3-1328
Abstract: Mass screening of adults was performed to manage employee healthcare. The screening service defined the data collection format as HL7 Clinical Document Architecture (CDA) R2. To capture mass screening data for nationwide electronic health records… read more here.
Keywords: cda; mapping hl7; mass screening; mass ... See more keywords
Use of Tox21 Screening Data to Evaluate the COVID-19 Drug Candidates for Their Potential Toxic Effects and Related Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.935399
Abstract: Currently, various potential therapeutic agents for coronavirus disease-2019 (COVID-19), a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are being investigated worldwide mainly through the drug repurposing approach. Several anti-viral, anti-bacterial,… read more here.
Keywords: tox21 screening; screening data; use tox21; drug ... See more keywords