Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28224
Abstract: Peptidyl‐prolyl cis–trans isomerase, NIMA‐interacting 1 (PIN1) is a peptidyl‐prolyl isomerase that binds phospho‐Ser/Thr‐Pro motifs in proteins and catalyzes the cis–trans isomerization of proline peptide bonds. PIN1 is overexpressed in several cancers including high‐grade serous ovarian… read more here.
Keywords: virtual screening; pin1 inhibitor; screening identifies; cancer ... See more keywords
Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia
Sign Up to like & getrecommendations! Published in 2019 at "Movement Disorders"
DOI: 10.1002/mds.27604
Abstract: Friedreich's ataxia is an autosomal‐recessive cerebellar ataxia caused by mutation of the frataxin gene, resulting in decreased frataxin expression, mitochondrial dysfunction, and oxidative stress. Currently, no treatment is available for Friedreich's ataxia patients. Given that… read more here.
Keywords: drug repositioning; friedreich ataxia; frataxin; ataxia ... See more keywords
Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.104649
Abstract: Herpesviral deubiquitinating enzymes (DUBs) were discovered in 2005, are highly conserved across the family, and are proving to be increasingly important players in herpesviral infection. EBV's DUB, BPLF1, is known to regulate both cellular and… read more here.
Keywords: bplf1; molecule screening; small molecule; screening identifies ... See more keywords
Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27670-1
Abstract: Zika virus (ZIKV) infection can be associated with neurological pathologies, such as microcephaly in newborns and Guillain-Barre syndrome in adults. Effective therapeutics are currently not available. As such, a comprehensive understanding of virus-host interactions may… read more here.
Keywords: screening identifies; zikv infection; tmem120a; infection ... See more keywords
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69431-y
Abstract: Bacteria are known to evade β-lactam antibiotic action by producing β-lactamases (BLs), including carbapenemases, which are able to hydrolyze nearly all available β-lactams. The production of BLs represents one of the best known and most… read more here.
Keywords: virtual screening; screening identifies; clinically relevant; identifies broad ... See more keywords
A yeast two-hybrid screening identifies novel Atg8a interactors in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2045535
Abstract: ABSTRACT Macroautophagy/autophagy-related protein Atg8/LC3 is important for autophagosome biogenesis and required for selective degradation of various substrates. In our recent study, we performed a yeast two-hybrid screening to identify proteins that interact with Atg8a, the… read more here.
Keywords: hybrid screening; two hybrid; novel atg8a; screening identifies ... See more keywords
BioID2 screening identifies KIAA1671 as an EPS8 proximal factor that marks sites of microvillus growth
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-11-0498
Abstract: Microvilli are defining morphological features of the apical surfaces in diverse epithelial tissues. To develop our understanding of microvillus biogenesis, we used a biotin proximity–labeling approach to uncover new molecules enriched near EPS8, a well-studied… read more here.
Keywords: kiaa1671 eps8; growth; bioid2 screening; screening identifies ... See more keywords
High‐content screening identifies inhibitors of oxidative stress‐induced parthanatos: cytoprotective and anti‐inflammatory effects of ciclopirox
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15344
Abstract: Excessive oxidative stress can induce PARP1‐mediated programmed necrotic cell death, termed parthanatos. Inhibition of parthanatos may be therapeutically beneficial in a wide array of diseases associated with tissue injury and inflammation. Our goal was to… read more here.
Keywords: content screening; screening identifies; stress; high content ... See more keywords
An in silico–in vitro pipeline for drug cardiotoxicity screening identifies ionic pro‐arrhythmia mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15915
Abstract: Before advancing to clinical trials, new drugs are screened for their pro‐arrhythmic potential using a method that is overly conservative and provides limited mechanistic insight. The shortcomings of this approach can lead to the mis‐classification… read more here.
Keywords: pipeline drug; vitro pipeline; drug cardiotoxicity; screening identifies ... See more keywords
Genome-Wide Screening Identifies Prognostic Long Noncoding RNAs in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/6640652
Abstract: Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis. Therefore, there is an urgent call for the investigation of novel biomarkers in HCC. In the present study, we identified 6 upregulated lncRNAs in… read more here.
Keywords: hepatocellular carcinoma; genome wide; identifies prognostic; prognostic long ... See more keywords
Neoantigen screening identifies EGFR L858R mutation immunogenicity in 1862 Chinese NSCLC patients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e21512
Abstract: e21512Background: Therapeutic vaccines targeting mutation-derived neoantigens prime T-cell responses and deliver long-term clinical benefit to patients. Last year we reported EGFR L858R mutation co... read more here.
Keywords: l858r mutation; neoantigen screening; identifies egfr; screening identifies ... See more keywords