In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies
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DOI: 10.1182/bloodadvances.2022007250
Abstract: Key Points In vivo CRISPR screens in AML define key interactors of the microenvironment, including integrins, immune modulators, and glycosylation. Eight in vivo–specific hits are recurrently associated with adverse prognosis: BTBD6, FERMT3, ILK, SLC19A1, TAP2,… read more here.
Keywords: crispr; screening murine; genome wide; wide crispr ... See more keywords