Synthesis and biological screening of some novel 6‐substituted 2‐alkylpyridazin‐3(2H)‐ones as anti‐inflammatory and analgesic agents
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900295
Abstract: Some novel derivatives of 2‐alkyl 6‐substituted pyridazin‐3(2H)‐ones were synthesized by condensation of 3,6‐dichloropyridazine with the sodium salt of benzyl cyanide, followed by hydrolysis and coupling with alkyl halides. The synthesized compounds were screened as cyclooxygenase… read more here.
Keywords: anti inflammatory; biological screening; novel substituted; substituted alkylpyridazin ... See more keywords
Synthesis and biological screening of a novel enaminone-grafted trithiocarbonate: a potential anticancer and antimicrobial agent
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02535-2
Abstract: A need exists to develop safe and efficacious medications to treat major diseases such as cancer and infectious diseases. In response to this need, we synthesized a novel enaminone, which structurally belongs to the trithiocarbonate… read more here.
Keywords: biological screening; screening novel; novel enaminone; synthesis biological ... See more keywords
Screening novel autoantigens targeted by serum IgG autoantibodies in immunorelated pancytopenia by SEREX
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DOI: 10.1007/s12185-017-2287-0
Abstract: Immunorelated pancytopenia (IRP) is characterized by pancytopenia caused by autoantibody-mediated destruction or suppression of bone marrow. However, the autoantigens targeted by autoantibodies in IRP remain unclear. In the present study, we screened novel autoantigens in… read more here.
Keywords: autoantigens targeted; immunorelated pancytopenia; uqcr10 antigen; novel autoantigens ... See more keywords
Screening for novel inhibitors of glutathione peroxidase
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DOI: 10.1016/j.freeradbiomed.2018.04.152
Abstract: Cancer cells have higher basal levels of reactive oxygen species (ROS) production, and altered expression of antioxidant enzymes, when compared to normal cells. At high levels, ROS can cause substantial cellular damage, often leading to… read more here.
Keywords: inhibitors glutathione; glutathione peroxidase; novel inhibitors; screening novel ... See more keywords
Screening novel candidates for mid-IR nonlinear optical materials from I3–V–VI4 compounds
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DOI: 10.1039/c6tc05510a
Abstract: Although numerous superior nonlinear optical (NLO) crystals for the UV-vis to the near-infrared (IR) region have been established, the development of an efficient NLO material capable of broadband second harmonic generation (SHG) in the mid-IR… read more here.
Keywords: vi4 compounds; candidates mid; screening novel; mid nonlinear ... See more keywords
In Silico Screening of Novel α1-GABAA Receptor PAMs towards Schizophrenia Based on Combined Modeling Studies of Imidazo [1,2-a]-Pyridines
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DOI: 10.3390/ijms22179645
Abstract: The ionotropic GABAA receptor (GABAAR) has been proven to be an important target of atypical antipsychotics. A novel series of imidazo [1,2-a]-pyridine derivatives, as selective positive allosteric modulators (PAMs) of α1-containing GABAARs with potent antipsychotic… read more here.
Keywords: gabaa receptor; imidazo pyridines; screening novel; silico screening ... See more keywords
Screening of Novel Bioactive Peptides from Goat Casein: In Silico to In Vitro Validation
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DOI: 10.3390/ijms23052439
Abstract: Food-derived bioactive peptides are of great interest to science and industry due to evolving drivers of food product innovation, including health and wellness. This study aims to draw attention through a critical study on how… read more here.
Keywords: vitro; bioactive peptides; screening novel; goat casein ... See more keywords
In Silico Screening for Novel Leucine Aminopeptidase Inhibitors with 3,4-Dihydroisoquinoline Scaffold
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DOI: 10.3390/molecules25071753
Abstract: Cancers are the leading cause of deaths worldwide. In 2018, an estimated 18.1 million new cancer cases and 9.6 million cancer-related deaths occurred globally. Several previous studies have shown that the enzyme, leucine aminopeptidase is… read more here.
Keywords: leucine aminopeptidase; aminopeptidase; novel leucine; silico screening ... See more keywords