Engineering of a chromogenic enzyme screening system based on an auxiliary indole‐3‐carboxylic acid monooxygenase
Sign Up to like & getrecommendations! Published in 2019 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.795
Abstract: Here, we present a proof‐of‐principle for a new high‐throughput functional screening of metagenomic libraries for the selection of enzymes with different activities, predetermined by the substrate being used. By this approach, a total of 21… read more here.
Keywords: screening system; indole carboxylic; carboxylic acid; system based ... See more keywords
Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2020.104960
Abstract: Abstract Coronavirus Disease 2019 (COVID-19) caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a crude case fatality rate of about 0.5-10% depending on locality. A few clinically approved drugs,… read more here.
Keywords: approved drugs; covid; two tier; screening system ... See more keywords
Preself-Feeding Medaka Fry Provides a Suitable Screening System for in Vivo Assessment of Thyroid Hormone-Disrupting Potential.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.1c06729
Abstract: Endocrine-disrupting chemicals are assessed based on their physiological potential and their potential associated adverse effects. However, suitable end points for detection of chemicals that interfere with the thyroid hormone (TH) system have not been established… read more here.
Keywords: system; screening system; feeding medaka; medaka fry ... See more keywords
Ligand Screening System for the RXRα Heterodimer Using the Fluorescence RXR Agonist CU-6PMN.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00509
Abstract: Retinoid X receptor (RXR), a nuclear receptor (NR) that regulates transcription of target genes in a ligand binding-dependent manner, is of interest as a drug target. RXR agonists have been developed as therapeutic agents for… read more here.
Keywords: rxr agonist; screening system; rxr heterodimers; rxr ... See more keywords
Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40692
Abstract: Despite numerous genetic studies on bone metabolism, understanding of the specific mechanisms is lacking. We developed an efficient screening system to identify novel genes involved in bone metabolism using mutant mouse strains registered with the… read more here.
Keywords: bone metabolism; screening system; trap;
Development of a Novel Scar Screening System with Machine Learning
Sign Up to like & getrecommendations! Published in 2022 at "Plastic and Reconstructive Surgery"
DOI: 10.1097/prs.0000000000009312
Abstract: Background: Hypertrophic scars and keloids tend to cause serious functional and cosmetic impediments to patients. As these scars are not life threatening, many patients do not seek proper treatment. Thus, educating physicians and patients regarding… read more here.
Keywords: system; screening system; scar screening; machine learning ... See more keywords
Low-Cost Assistive Body Temperature Screening System to Combat Communicable Infectious Diseases Leveraging Edge Computing and Long-Range and Low-Power Wireless Networks
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Internet of Things Journal"
DOI: 10.1109/jiot.2022.3215484
Abstract: In recent days, due to the emergence of communicable infectious diseases, healthcare, and medical technologies are expected to play a critical role. The advancement of communication and sensor network technologies has accelerated mass screening systems… read more here.
Keywords: screening system; infectious diseases; cost; temperature ... See more keywords
THU0148 Screening system for early arthritis with health professional assistants – a project of the t2t initiative in germany
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.6969
Abstract: Background Early stages of rheumatic diseases are still difficult to diagnose and treatment is delayed often due to the lack of practicing rheumatologists. Therefore, novel ways of diagnostic strategies are urgently needed. Objectives Evaluation of… read more here.
Keywords: screening system; health professional; appointment; professional assistants ... See more keywords
Rational high-throughput screening system for high sophorolipids production in Candida bombicola by co-utilizing glycerol and glucose capacity
Sign Up to like & getrecommendations! Published in 2019 at "Bioresources and Bioprocessing"
DOI: 10.1186/s40643-019-0252-x
Abstract: BackgroundA rational and high-performance high-throughput screening system effectively improves the efficiency of strain screening.ResultsA rapid and efficient method was developed to detect carbon sources. And then by using glucose analog as screening pressure and two… read more here.
Keywords: production; high throughput; rational high; glycerol ... See more keywords
Establishing an accurate and sensitive in vitro drug screening system for human adenovirus infection with human corneal cells.
Sign Up to like & getrecommendations! Published in 2023 at "Virology"
DOI: 10.2139/ssrn.4330561
Abstract: Epidemic keratoconjunctivitis (EKC) is a hazardous and highly contagious disease, with the potential to cause epidemic outbreaks in hospitals and other community settings. There are currently no approved drugs for human adenovirus (HAdV), the causative… read more here.
Keywords: drug screening; system; human adenovirus; screening system ... See more keywords
Evaluation of the High-Throughput Screening System for Assessing the Behavioral Response of Female Aedes aegypti to Natural Products.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Mosquito Control Association"
DOI: 10.2987/21-7039
Abstract: As part of an arbovirus vector control strategy, chemical control continues to be a mainstay in mitigating the burden of disease. The current arsenal of chemicals used for this purpose, however, are becoming challenged rapidly… read more here.
Keywords: aedes aegypti; screening system; natural products; throughput screening ... See more keywords