Structure-based virtual screening workflow to identify antivirals targeting HIV-1 capsid
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-022-00446-5
Abstract: We have identified novel HIV-1 capsid inhibitors targeting the PF74 binding site. Acting as the building block of the HIV-1 capsid core, the HIV-1 capsid protein plays an important role in the viral life cycle… read more here.
Keywords: structure based; screening workflow; capsid; hiv capsid ... See more keywords
Unattended screening workflow in a 384-well automated patch clamp system
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmacological and Toxicological Methods"
DOI: 10.1016/j.vascn.2021.106970
Abstract: Within ion channel working group efforts (Fermini et al., 2015), reference compounds were tested across multiple sites and automated patch clamp (APC) platforms (Kramer et al., 2020). Resulting IC50 values were variable between drugs and… read more here.
Keywords: patch clamp; unattended screening; screening workflow; automated patch ... See more keywords