Binding pocket stabilization by high-throughput screening of yeast display libraries
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.1023131
Abstract: Protein dynamics have a great influence on the binding pockets of some therapeutic targets. Flexible protein binding sites can result in transient binding pocket formation which might have a negative impact on drug screening efforts.… read more here.
Keywords: throughput screening; high throughput; screening yeast; binding pocket ... See more keywords
Screening of Yeast Display Libraries of Enzymatically Treated Peptides to Discover Macrocyclic Peptide Ligands
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DOI: 10.3390/ijms22041634
Abstract: We present the construction and screening of yeast display libraries of post-translationally modified peptides wherein site-selective enzymatic treatment of linear peptides is achieved using bacterial transglutaminase. To this end, we developed two alternative routes, namely… read more here.
Keywords: peptide; yeast display; display libraries; treated peptides ... See more keywords