A high-dimensional, stochastic model for twin-screw granulation Part 2: Numerical methodology
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Engineering Science"
DOI: 10.1016/j.ces.2018.04.077
Abstract: Abstract In the second part of this study, we present the stochastic weighted particle population balance framework used to solve the twin-screw granulation model detailed in the first part of this study. Each stochastic jump… read more here.
Keywords: methodology; high dimensional; part; twin screw ... See more keywords
Impact of fill‐level in twin‐screw granulation on critical quality attributes of granules and tablets
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DOI: 10.1016/j.ejpb.2017.02.010
Abstract: &NA; In a previous study a change of the fill‐level in the barrel exerted a huge influence on the twin‐screw granulation (TSG) process of a high drug loaded, simplified formulation. The present work investigated this… read more here.
Keywords: twin screw; fill level; screw granulation; level ... See more keywords
Process monitoring and evaluation of a continuous pharmaceutical twin‐screw granulation and drying process using multivariate data analysis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.04.011
Abstract: Graphical abstract Figure. No caption available. Abstract The present study aims at acquiring an in‐depth process knowledge about a twin‐screw granulation and fluid bed drying process performed on the commercially available continuous line. Batch Statistical… read more here.
Keywords: twin screw; screw granulation; drying process; process ... See more keywords
A comprehensive analysis and optimization of continuous twin-screw granulation processes via sequential experimentation strategy.
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DOI: 10.1016/j.ijpharm.2018.12.009
Abstract: Nowadays twin-screw granulation has been emerging as an attractive continuous wet granulation technique. This study was geared towards better process design and understanding with emphasis on bridging the knowledge gap between input and output variables… read more here.
Keywords: sequential experimentation; experimentation strategy; granulation; twin screw ... See more keywords
Tailored granule properties using 3D printed screw geometries in twin screw granulation
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DOI: 10.1016/j.powtec.2017.12.068
Abstract: Abstract Twin screw granulation is becoming increasingly relevant due to its compact size, continuous and robust mode of operation, customizable design, and flexible production capacity. This work describes the experimental study undertaken to understand the… read more here.
Keywords: twin screw; granule properties; screw granulation; geometry ... See more keywords
DEM analysis of residence time distribution during twin screw granulation
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DOI: 10.1016/j.powtec.2020.09.049
Abstract: Abstract Twin screw granulation (TSG) is increasingly used to produce granules in various industries, such as food, pharmaceutical, and fine chemicals. However, there is a large parametric space in terms of screw designs, formulation properties… read more here.
Keywords: screw granulation; twin screw; residence time; residence ... See more keywords