Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.04.055
Abstract: In this study, the influence of key process variables (screw speed, throughput and liquid to solid (L/S) ratio) of a continuous twin screw wet granulation (TSWG) was investigated using a central composite face-centered (CCF) experimental… read more here.
Keywords: design; twin screw; screw wet; process ... See more keywords
Integrated Twin-Screw Wet Granulation, Continuous Vibrational Fluid Drying and Milling: A fully continuous powder to granule line.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.120126
Abstract: Highly homogeneous low-dose (50 µg) tablets were produced incorporating perfectly free-flowing granules prepared by a fully integrated Continuous Manufacturing (CM) line. The adopted CM equipment consisted of a Twin-Screw Wet Granulator (TSWG), a Continuous Fluid… read more here.
Keywords: granulation; line; twin screw; fluid ... See more keywords