Sculpting ion channel functional expression with engineered ubiquitin ligases
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DOI: 10.7554/elife.29744
Abstract: The functional repertoire of surface ion channels is sustained by dynamic processes of trafficking, sorting, and degradation. Dysregulation of these processes underlies diverse ion channelopathies including cardiac arrhythmias and cystic fibrosis. Ubiquitination powerfully regulates multiple… read more here.
Keywords: channel functional; ion channel; expression; ion ... See more keywords