Formulation optimization of scutellarin-loaded HP-β-CD/chitosan nanoparticles using response surface methodology with Box–Behnken design
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2017.04.003
Abstract: Graphical Abstract The scutellarin (SCU)-loaded HP-β-CD/chitosan (CS) nanoparticles (CD/CS-SCU-NPs) were prepared using ionic gelation method. Response surface design was used to optimize the formulation. The optimum formulation was tested in vitro. Unlabelled image read more here.
Keywords: methodology; loaded chitosan; scutellarin; chitosan nanoparticles ... See more keywords
Scutellarin protects against lipopolysaccharide-induced behavioral deficits by inhibiting neuroinflammation and microglia activation in rats.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106943
Abstract: Depression is a complex and heterogeneous mental disorder. Yet, the mechanisms behind depression remain elusive. Increasing evidence suggests that inflammatory reaction and microglia activation are involved in the pathogenesis of depression. Scutellarin has been found… read more here.
Keywords: activation; scutellarin; microglia activation; lps induced ... See more keywords
RGD and Scutellarin Conjugate (WK001) Targeting Platelet Glycoprotein IIb/IIIa Receptor Protects from Myocardial Ischemia/Reperfusion Injury: Synthesis, Characterization, and Bioactivity Evaluation.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00439
Abstract: Myocardial ischemia/reperfusion (MI/R) injury is an unresolved clinical challenge. The blockade of binding fibrinogen by glycoprotein IIb/IIIa (GPIIb-IIIa) inhibitors has become a new therapeutic approach against MI/R injury. In this study, we modified the RGD… read more here.
Keywords: iiia; myocardial ischemia; scutellarin; wk001 ... See more keywords
Scutellarin alleviates lipopolysaccharide-provoked septic nephrotoxicity via attenuation of inflammatory and oxidative events and mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2141644
Abstract: Abstract Background Sepsis-associated acute kidney injury (AKI) is highlighted by high incidence of mortality and morbidity. Scutellarin is a flavone extracted from certain medicinal plants with anti-inflammatory and anti-oxidative properties. This research study was done… read more here.
Keywords: scutellarin alleviates; factor; scutellarin; gene expression ... See more keywords
A study on distribution and stability of drugs at the interface of a scutellarin-loaded emulsion
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2021.1944204
Abstract: Abstract This work mainly studies the interfacial behaviors of scutellarin on a newly developed emulsion and establishes a three-phase distribution model. The results showed that the concentration of scutellarin could decrease the interfacial tension and… read more here.
Keywords: phase; scutellarin; drugs interface; stability ... See more keywords
Preparation and characterization of scutellarin loaded on ultradeformable nano-liposomes scutellarin EDTMP (S-UNL-E) and in vitro study of its osteogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2016095
Abstract: ABSTRACT The present research aimed to elucidate a convenient, safe and economic approach to induce the growth of endogenous bone tissue and bone regeneration. S-UNL-E was prepared using reverse-phase evaporation, and scutellarin encapsulation was subsequently… read more here.
Keywords: preparation characterization; preparation; characterization scutellarin; scutellarin loaded ... See more keywords
Scutellarin Loaded on Ultradeformable Nanoliposome Scutellarin EDTMP (S-UNL-E) Promotes Osteogenesis in Osteoporotic Rats
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells International"
DOI: 10.1155/2022/1395299
Abstract: Scutellarin is known as a safe, effective, and low-cost traditional Chinese medicine and has a variety of biological activities. Studies reported that the scutellarin loaded on ultradeformable nanoliposome scutellarin EDTMP (S-UNL-E) could promote osteoblast differentiation… read more here.
Keywords: loaded ultradeformable; scutellarin loaded; nanoliposome scutellarin; scutellarin ... See more keywords
Scutellarin Suppresses NLRP3 Inflammasome Activation in Macrophages and Protects Mice against Bacterial Sepsis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00975
Abstract: The NLRP3 inflammasome plays a critical role in mediating the innate immune defense against pathogenic infections, but aberrant activation of NLRP3 inflammasome has been linked to a variety of inflammatory diseases. Thus targeting the NLRP3… read more here.
Keywords: sepsis; inflammasome activation; scutellarin; activation macrophages ... See more keywords
Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7292
Abstract: Scutellarin is the major effective constituent of the commonly used Chinese medicine Erigeron breviscapus. It has been applied in the clinic to treat various diseases, and is characterized by high content, a stable source, controllable… read more here.
Keywords: medicine; scutellarin; inflammation; collagen induced ... See more keywords