Concise syntheses and some biological activities of dl‐2,5‐di‐O‐methyl‐chiro‐inositol, dl‐1,4‐di‐O‐methyl‐scyllo‐inositol, and dl‐1,6‐dibromo‐1,6‐dideoxy‐2,5‐di‐O‐methyl‐chiro‐inositol
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000254
Abstract: The regio‐ and stereospecific synthesis of O‐methyl‐chiro‐inositols and O‐methyl‐scyllo‐inositol was achieved, starting from p‐benzoquinone. After preparing dimethoxy conduritol‐B as a key compound, regiospecific bromination of the alkene moiety of dimethoxy conduritol‐B and acid‐catalyzed ring opening… read more here.
Keywords: methyl chiro; inositol; chiro; chiro inositol ... See more keywords
Plasma and urinary inositol isomer profiles measured by UHPLC-MS/MS reveal differences in scyllo-inositol levels between non-pregnant and pregnant women
Sign Up to like & getrecommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-020-02919-8
Abstract: Previous studies support that myo- and d-chiro-inositol isomers are promising bioactives for the treatment of women with polycystic ovary syndrome and for lowering the risk of gestational diabetes mellitus in pregnant women, whereas scyllo-inositol may… read more here.
Keywords: inositol; pregnant women; pregnant pregnant; inositol isomer ... See more keywords
Metabolic engineering of Corynebacterium glutamicum for production of scyllo-inositol, a drug candidate against Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2021.06.011
Abstract: Scyllo-inositol has been identified as a potential drug for the treatment of Alzheimer's disease. Therefore, cost-efficient processes for the production of this compound are desirable. In this study, we analyzed and engineered Corynebacterium glutamicum with… read more here.
Keywords: myo inositol; inositol; scyllo inositol; production ... See more keywords
Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087598
Abstract: Epilepsy, with about 70 million affected people worldwide, is one of the biggest challenges of medicine today. It is estimated that about one-third of epileptic patients receive inadequate treatment. Inositols have proved effective in many… read more here.
Keywords: sci; properties scyllo; induced seizures; pentylenetetrazol induced ... See more keywords