hiPSC‐Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial‐Like Cells
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DOI: 10.1002/glia.70085
Abstract: Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ). Yet, the crosstalk between astrocytes and microglia in SCZ, especially under pro-inflammatory conditions, remains unclear. Here, we employed human induced-pluripotent stem cells to compare how… read more here.
Keywords: reactive scz; like cells; microglial like; scz astrocytes ... See more keywords
Meta‐analytic evidence for altered mesolimbic responses to reward in schizophrenia
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DOI: 10.1002/hbm.24049
Abstract: Dysfunction of reward‐related neural circuitry in schizophrenia (SCZ) has been widely reported, and may provide insight into the motivational and cognitive disturbances that characterize the disorder. Although previous meta‐analyses of reward learning paradigms in SCZ… read more here.
Keywords: functional connectivity; scz; schizophrenia; analysis ... See more keywords
Autophagy and Schizophrenia.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-4272-5_13
Abstract: Schizophrenia (SCZ) is characterized by abnormal thoughts, behaviors and speech, along with a decreased perception of reality that can included visual or auditory hallucinations, withdrawal of social activity and lack of motivation, etc. Many hypotheses… read more here.
Keywords: autophagy schizophrenia; scz; biology;
Dysregulation of Fibroblast Growth Factor 10 in the Peripheral Blood of Patients with Schizophrenia
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DOI: 10.1007/s12031-019-01331-x
Abstract: The fibroblast growth factor (FGF) system has been suggested to be involved in the development of schizophrenia (SCZ). However, the potential roles of all FGFs have not been well studied in the literature. Here, we… read more here.
Keywords: fgf10; scz; fibroblast growth; growth factor ... See more keywords
Associations between major psychiatric disorder polygenic risk scores and blood-based markers in UK biobank
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DOI: 10.1016/j.bbi.2021.06.002
Abstract: Major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD) have both shared and discrete genetic risk factors and abnormalities in blood-based measures of inflammation and blood-brain barrier (BBB) permeability. The relationships between such genetic… read more here.
Keywords: risk; prs; scz; disorder ... See more keywords
Evaluating the Impact of Nonrandom Mating: Psychiatric Outcomes Among the Offspring of Pairs Diagnosed With Schizophrenia and Bipolar Disorder
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DOI: 10.1016/j.biopsych.2019.06.025
Abstract: BACKGROUND Nonrandom mating has been shown for psychiatric diagnoses, with hypothesized-but not quantified-implications for offspring liability. This national cohort study enumerated the incidence of major psychiatric disorders among the offspring of parent pairs affected with… read more here.
Keywords: scz; among offspring; disorder; bipolar disorder ... See more keywords
58 GENOMIC DISSECTION OF BIPOLAR DISORDER AND SCHIZOPHRENIA IN 50K CASES, 50K CONTROLS AND 28 SUBPHENOTYPES
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DOI: 10.1016/j.euroneuro.2017.08.059
Abstract: Background Schizophrenia (SCZ) and Bipolar Disorder (BD) are heritable disorders (h2 ~ 0.8) that share a significant proportion of common genetic factors (genetic correlation (rg) ~ 0.6). Understanding the genetic factors underlying the specific symptoms… read more here.
Keywords: genome wide; scz; gws; bipolar disorder ... See more keywords
SU113 POLYGENIC RISK BURDEN AND CANNABIS USE COMORBIDITY IN PATIENTS WITH SCHIZOPHRENIA AND BIPOLAR DISORDER
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.302
Abstract: Background Cannabis is the most widely used illicit drug in the world. It is well established that substance abuse comorbidity i.a. cannabis use is much higher among patients with Schizophrenia (SCZ) and Bipolar Disorders (BD)… read more here.
Keywords: cannabis; scz; cannabis use; use ... See more keywords
Intelligence decline between present and premorbid IQ in schizophrenia: Schizophrenia Non-Affected Relative Project (SNARP)
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2019.03.003
Abstract: Schizophrenia patients (SCZ) display widespread cognitive deficits that are strongly associated with functional outcomes. Cognitive impairments occur along a genetic continuum among SCZ, their unaffected first-degree relatives (FRs) and healthy controls (HCs). Although SCZ impairs… read more here.
Keywords: schizophrenia; scz; premorbid; intelligence decline ... See more keywords
Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases.
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DOI: 10.1016/j.gene.2017.10.035
Abstract: Schizophrenia (SCZ) is a chronic debilitating neuropsychiatric disorder with multiple risk factors involving numerous complex genetic influences. We examined and updated a master list of clinically relevant and susceptibility genes associated with SCZ reported in… read more here.
Keywords: scz; schizophrenia; analysis; program integrated ... See more keywords
The causal relationships of device-measured physical activity with bipolar disorder and schizophrenia in adults: A 2-Sample mendelian randomization study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2019.11.034
Abstract: BACKGROUND To examine the causal association of device-measured physical activity with Bipolar disorder (BIP) and schizophrenia (SCZ) in adults by performing 2-sample MR analysis. METHODS Summary-level data for exposure variable including overall physical activity, and… read more here.
Keywords: device measured; scz; measured physical; activity bipolar ... See more keywords