Paratope Duality and Gullying are Among the Atypical Recognition Mechanisms Used by a Trio of Nanobodies to Differentiate Ebolavirus Nucleoproteins
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.10.005
Abstract: We had previously shown that three anti–Marburg virus nanobodies (VHH or single-domain antibody [sdAb]) targeted a cryptotope within an alpha-helical assembly at the nucleoprotein (NP) C-terminus that was conserved through half a century of viral… read more here.
Keywords: ebolavirus; gullying among; duality gullying; sdab ... See more keywords
Incorporation of a Novel CD16-Specific Single-Domain Antibody into Multispecific Natural Killer Cell Engagers With Potent ADCC.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00208
Abstract: Multispecific antibodies that bridge immune effector and tumor cells have shown promising preclinical and clinical efficacies. Here, we isolated and characterized novel llama single-domain antibodies (sdAbs) against CD16. One sdAb, NRC-sdAb048, bound recombinant human and… read more here.
Keywords: incorporation novel; single domain; cd16; anti cd16 ... See more keywords
Theranostic Radiolabeled Anti-CD20 sdAb for Targeted Radionuclide Therapy of Non-Hodgkin Lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-17-0554
Abstract: Anti-CD20 radioimmunotherapy is an effective approach for therapy of relapsed or refractory CD20pos lymphomas, but faces limitations due to poor tumor penetration and undesirable pharmacokinetics of full antibodies. Camelid single-domain Ab fragments (sdAb) might circumvent… read more here.
Keywords: sdab 9079; sdab; anti cd20; therapy ... See more keywords
Abstract 1885: Selection of an optimal anti-PD-L1 single domain antibody format for the vectorization into oncolytic vaccinia virus and the generation of bispecific immunomodulators
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1885
Abstract: Background: Single domain antibodies (sdAbs) isolated after immunization of camelids are particularly attractive formats for their high modularity and small size allowing a better diffusion into tumors. However, the short in vivo half-life of sdAbs,… read more here.
Keywords: oncolytic vaccinia; sdab; domain; activity ... See more keywords
Oxford nanopore sequencing enables rapid discovery of single-domain antibodies from phage display libraries.
Sign Up to like & getrecommendations! Published in 2018 at "BioTechniques"
DOI: 10.2144/btn-2018-0123
Abstract: Antibody (Ab) repertoire sequencing using high-throughput massively parallel technologies has contributed substantially to the understanding of Ab responses following infection, vaccination and autoimmunity. Because individual B-cell receptors are recombined and diversified somatically, genomic comparisons are… read more here.
Keywords: phage display; display libraries; single domain; nanopore sequencing ... See more keywords