Knee Loading Enhances the Migration of Adipose-Derived Stem Cells to the Osteoarthritic Sites Through the SDF-1/CXCR4 Regulatory Axis.
Sign Up to like & getrecommendations! Published in 2022 at "Calcified tissue international"
DOI: 10.1007/s00223-022-00976-y
Abstract: Osteoarthritis (OA) is a whole joint disorder that is characterized by cartilage damage and abnormal remodeling of subchondral bone. Injecting adipose-derived stem cells (ASCs) into the knee joint cavity can assist in repairing osteoarthritic joints,… read more here.
Keywords: migration ascs; migration; sdf cxcr4; knee loading ... See more keywords
Activated hepatic stellate cells regulate MDSC migration through the SDF-1/CXCR4 axis in an orthotopic mouse model of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02414-9
Abstract: Hepatic stellate cells (HSCs) are important stromal cells and pivotal mediators involved in the pathogenesis and immunosuppression of hepatocellular carcinoma (HCC). The liver has been demonstrated to be a site for accumulation of tumor-induced myeloid-derived… read more here.
Keywords: sdf cxcr4; hcc; cxcr4 axis; mdsc migration ... See more keywords
Rongjin Niantong Fang ameliorates cartilage degeneration by regulating the SDF-1/CXCR4-p38MAPK signalling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2143533
Abstract: Abstract Context Rongjin Niantong Fang (RJNTF) is a Traditional Chinese Medicine formulation with a good therapeutic effect on osteoarthritis (OA). However, the underlying mechanisms remain unclear. Objective This study investigates whether RJNTF could delay OA… read more here.
Keywords: cxcr4 p38mapk; p38mapk signalling; sdf cxcr4; group ... See more keywords
R4 RGS proteins suppress engraftment of human hematopoietic stem/progenitor cells by modulating SDF-1/CXCR4 signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Blood advances"
DOI: 10.1182/bloodadvances.2020003307
Abstract: Homing and engraftment of hematopoietic stem/progenitor cells (HSPCs) into the bone marrow (BM) microenvironment are tightly regulated by the chemokine SDF-1 and its G-protein-coupled receptor CXCR4, which on engagement with G-protein subunits, trigger downstream migratory… read more here.
Keywords: sdf cxcr4; progenitor cells; stem progenitor; hematopoietic stem ... See more keywords
Molecular Mechanism of Integrin αvβ6 in Liver Metastasis of Colon Cancer Based on SDF-1/CXCR4.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2021.67.6.12
Abstract: With the changes in people's dietary life, the incidence and mortality of colon cancer have risen sharply. Invasive metastasis of colon cancer is the main reason affecting the prognosis. Therefore, it is very important to… read more here.
Keywords: metastasis; colon cancer; cancer; sdf cxcr4 ... See more keywords
Effect of integrin α5β1 inhibition on SDF-l/CXCR4-mediated choroidal neovascularization.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2018.05.04
Abstract: AIM To investigate the roles of integrins in choroidal neovascularization (CNV) and their associations with the stromal cell-derived factor-1 (SDF-1)/CXCR4 axis. METHODS CNV lesions were induced in mice using laser photocoagulation. After CNV induction, all… read more here.
Keywords: sdf cxcr4; choroidal neovascularization; integrin; cnv ... See more keywords
The SDF-1/CXCR4 axis promotes recovery after spinal cord injury by mediating bone marrow-derived from mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14619
Abstract: This study aims to explore the role of the SDF-1/CXCR4 axis in mediating BMSCs and SCI recovery. BMSCs were collected and SCI rat models were established. Wistar rats were assigned into the blank control, sham,… read more here.
Keywords: sdf cxcr4; sci; cxcr4 axis; sci bmscs ... See more keywords
Association of SDF-1 and CXCR4 Polymorphisms With Susceptibility to Oral and Pharyngeal Squamous Cell Carcinoma
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DOI: 10.21873/anticanres.13418
Abstract: Background/Aim: Long-term exposure to betel quid (BQ)-, cigarette-, and alcohol-induced chronic inflammation is a crucial risk factor for oral and pharyngeal squamous cell carcinoma (OPSCC) progression. We analyzed the genotypes of stromal-cell-derived factor-1 (SDF-1) and… read more here.
Keywords: sdf cxcr4; risk; susceptibility; oral pharyngeal ... See more keywords
Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
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DOI: 10.3390/cancers13081793
Abstract: Simple Summary The SDF-1α/CXCR4 axis plays crucial roles in proliferation, survival, invasion, dissemination, and drug resistance in multiple myeloma. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and introduces the… read more here.
Keywords: sdf cxcr4; cxcr4 axis; multiple myeloma; myeloma ... See more keywords
Modulation of Prostanoids Profile and Counter-Regulation of SDF-1α/CXCR4 and VIP/VPAC2 Expression by Sitagliptin in Non-Diabetic Rat Model of Hepatic Ischemia-Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222313155
Abstract: Molecular mechanisms underlying the beneficial effect of sitagliptin repurposed for hepatic ischemia-reperfusion injury (IRI) are poorly understood. We aimed to evaluate the impact of IRI and sitagliptin on the hepatic profile of eicosanoids (LC-MS/MS) and… read more here.
Keywords: reperfusion; sitagliptin; expression; sdf cxcr4 ... See more keywords
SDF-1α/CXCR4 signaling promotes capillary tube formation of human retinal vascular endothelial cells by activating ERK1/2 and PI3K pathways in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12821
Abstract: The purpose of this study is to address the effect and mechanism of stromal cell-derived factor-1 (SDF-1)α/chemokine (C-X-C motif) receptor 4 (CXCR4) signaling on capillary tube formation of human retinal vascular endothelial cells (HRECs). The… read more here.
Keywords: cxcr4 signaling; sdf cxcr4; cxcr4; tube formation ... See more keywords