Hypothesis: Why Different Types of SDH Gene Variants Cause Divergent Tumor Phenotypes
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DOI: 10.3390/genes13061025
Abstract: Despite two decades of paraganglioma-pheochromocytoma research, the fundamental question of how the different succinate dehydrogenase (SDH)-related tumor phenotypes are initiated has remained unanswered. Here, we discuss two possible scenarios by which missense (hypomorphic alleles) or… read more here.
Keywords: succinate; tumor phenotypes; variants cause; gene variants ... See more keywords