Enhancing KCC2 function counteracts morphine-induced hyperalgesia
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04209-3
Abstract: Morphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl− extruder KCC2 in the superficial… read more here.
Keywords: morphine induced; treatment; sdh neurons; enhancing kcc2 ... See more keywords