SDHA/B reduction promotes hepatocellular carcinoma by facilitating the deNEDDylation of cullin1 and stabilizing YAP/TAZ.
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DOI: 10.1002/hep.32621
Abstract: BACKGROUND & AIMS Succinate dehydrogenase enzyme (SDH) is frequently diminished in Hepatocellular carcinoma (HCC) patient samples, and SDH reduction is associated with elevated succinate level and poor prognosis in HCC patients. But the underlying mechanisms… read more here.
Keywords: hcc; sdha reduction; taz; yap taz ... See more keywords