The utility of SDHB and FH immunohistochemistry in patients evaluated for hereditary paraganglioma-pheochromocytoma syndromes.
Sign Up to like & getrecommendations! Published in 2018 at "Human pathology"
DOI: 10.1016/j.humpath.2017.10.013
Abstract: A significant portion of paragangliomas (PGL) and pheochromocytomas (PCC) occur in patients with hereditary PGL/PCC syndromes, including those with germline mutations in succinate dehydrogenase (SDHx) subunit genes. Recently, germline fumarate hydratase (FH) mutations have been… read more here.
Keywords: pgl pcc; pcc; sdhb immunohistochemistry; ihc ... See more keywords
An exploration in pitfalls in interpreting SDHB immunohistochemistry
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DOI: 10.1111/his.14681
Abstract: Mutations and epimutations in genes encoding the succinate dehydrogenase complex (SDHx) are associated with multiple tumour types in which identification of SDH‐deficiency has significant management implications. Immunohistochemistry (IHC) for the succinate dehydrogenase B (SDHB) subunit… read more here.
Keywords: exploration pitfalls; interpreting sdhb; sdhb immunohistochemistry; pitfalls interpreting ... See more keywords