SDHB and SDHD silenced pheochromocytoma spheroids respond differently to tumour microenvironment and their aggressiveness is inhibited by impairing stroma metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2022.111594
Abstract: Germline mutations in more than 20 genes, including those encoding for the succinate dehydrogenase (SDH), predispose to rare tumours, such as pheochromocytoma/paraganglioma (PPGL). Despite encoding for the same enzymatic complex, SDHC and SDHD mutated PHEO/PGLs… read more here.
Keywords: sdhd; metabolism; sdhb sdhd; migration ... See more keywords
SDHD promoter mutations are rare events in cutaneous melanomas but SDHD protein expression is downregulated in advanced cutaneous melanoma
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DOI: 10.1371/journal.pone.0180392
Abstract: Background SDHD promoter mutations were reported in 4–10% of cutaneous melanomas. The advanced clinico-pathological and patient survival association with SDHD mutation and/or expression in cutaneous melanoma remains controversial. Objectives To evaluate the presence of SDHD… read more here.
Keywords: protein expression; sdhd; sdhd promoter; expression ... See more keywords