Abstract 7230: New mouse strains NSG-SGM3xIL15xDKO and NSG- FLT3LxDKO are superior to NSG-MHC I/II DKO mice for humanization of peripheral blood mononuclear cells
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DOI: 10.1158/1538-7445.am2025-7230
Abstract: Peripheral blood mononuclear cells (PBMC)-humanized mice serve as important platforms to evaluate efficacy and toxicity. NSG-MHC I/II double-knock out (DKO) mice have been widely used due to being a humanized T cell model with delayed… read more here.
Keywords: mice; dko; sdko fdko; dko mice ... See more keywords
Abstract 7235: New mouse strain NSG-SGM3xIL15xDKO is better for PBMC engraftment in Raji-bearing mice of minor immune subsets compared to NSG-MHC I/II DKO mouse
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DOI: 10.1158/1538-7445.am2025-7235
Abstract: PBMC-humanized MHC I/II double knock-out (#025216, DKO) strain has shown strong T cell engraftment with minimal acute GVHD. We recently have developed two new mouse strains, NSG-SGM3xIL15xDKO (SDKO) and NSG-FLT3LxDKO (FDKO), and their engraftment comparison… read more here.
Keywords: raji luc; dko; sdko fdko; luc ... See more keywords