d‐amino acid modification protects N‐Acetyl‐seryl‐aspartyl‐lysyl‐proline from physiological hydroxylation and increases its antifibrotic effects on hepatic fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2037
Abstract: N‐Acetyl‐seryl‐aspartyl‐lysyl‐proline (Ac‐SDKP) is a critical negative regulator of fibrosis development in the liver. However, its extremely short half‐life in vivo greatly compromises its potential applications. Here, we report an Ac‐SDKP analog peptide with d‐amino acid… read more here.
Keywords: acetyl seryl; seryl aspartyl; amino acid; fibrosis ... See more keywords
Therapeutic effect of N-Acetyl-Seryl-Aspartyl-Proline and Vasoactive Intestinal Peptide on COPD pathophysiology.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23057
Abstract: COPD as an inflammatory respiratory system disease is caused by exposure to cigarette smoke and tobacco in long-term. Some anti-inflammatory peptides can control inflammation in COPD. Ac-SDKP and VIP as peptide have anti-inflammatory effect and,… read more here.
Keywords: copd; inflammation; effect; sdkp ... See more keywords
Renal Protective Effects of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) in Obese Rats on a High-Salt Diet
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hypertension"
DOI: 10.1093/ajh/hpy052
Abstract: Abstract BACKGROUND Obesity is a public health problem, associated with salt sensitive hypertension, kidney inflammation, and fibrosis. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a tetra peptide with anti-inflammatory and anti-fibrotic properties. However, its effect on preventing kidney damage… read more here.
Keywords: inflammation fibrosis; acetyl seryl; sdkp; salt diet ... See more keywords
N-Acetyl-Seryl-Asparyl-Lysyl-Proline interaction with ACE2-Ang (1-7)-Mas axis attenuates pulmonary fibrosis in silicotic rats.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental physiology"
DOI: 10.1113/ep087515
Abstract: NEW FINDINGS What is the central question of this study? To explore the effects of Ac-SDKP on ACE2/Ang (1-7)/Mas axis in occurrence and progress of silicosis. What is the main finding and its importance? Ac-SDKP… read more here.
Keywords: silicosis; ace2 ang; ang mas; ang ... See more keywords