Absence of the highly expressed small carbohydrate-binding protein Cgt improves the acarbose formation in Actinoplanes sp. SE50/110
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10584-1
Abstract: Actinoplanes sp. SE50/110 (ATCC 31044) is the wild type of industrial producer strains of acarbose. Acarbose has been used since the early 1990s as an inhibitor of intestinal human α-glucosidases in the medical treatment of… read more here.
Keywords: actinoplanes se50; carbohydrate binding; cgt; protein cgt ... See more keywords
Improving acarbose production and eliminating the by-product component C with an efficient genetic manipulation system of Actinoplanes sp. SE50/110
Sign Up to like & getrecommendations! Published in 2017 at "Synthetic and Systems Biotechnology"
DOI: 10.1016/j.synbio.2017.11.005
Abstract: The α-glucosidase inhibitor acarbose is commercially produced by Actinoplanes sp. and used as a potent drug in the treatment of type-2 diabetes. In order to improve the yield of acarbose, an efficient genetic manipulation system… read more here.
Keywords: efficient genetic; system; genetic manipulation; component ... See more keywords
Comparative functional genomics of the acarbose producers reveals potential targets for metabolic engineering
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic and Systems Biotechnology"
DOI: 10.1016/j.synbio.2019.01.001
Abstract: The α-glucosidase inhibitor acarbose is produced in large-scale by strains derived from Actinoplanes sp. SE50 and used widely for the treatment of type-2 diabetes. Compared with the wild-type SE50, a high-yield derivative Actinoplanes sp. SE50/110… read more here.
Keywords: engineering; acarbose yield; acb cluster; yield ... See more keywords