Virtual Screening in Search of Allosteric Modulators of Nav1.1 Channels
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DOI: 10.1016/j.bpj.2016.11.1325
Abstract: Voltage-gated Na+ (Nav) channels provide the basis for neuronal excitability in the brain. Of the nine Nav channel isoforms (Nav1.1-Nav1.9), Nav1.1 exhibits cell-specific distribution in fast-spiking parvalbumin (PV) interneurons in the cortical circuit. Reduced function… read more here.
Keywords: virtual screening; search allosteric; fgf14 nav1; screening search ... See more keywords