Resolving the subtle details of human DNA alkyltransferase lesion search and repair mechanism by single-molecule studies
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DOI: 10.1073/pnas.2116218119
Abstract: Significance We directly visualize DNA translocation and lesion recognition by the O6-alkylguanine DNA alkyltransferase (AGT). Our data show bidirectional movement of AGT monomers and clusters on undamaged DNA that depended on Zn2+ occupancy of AGT.… read more here.
Keywords: dna; lesion search; dna alkyltransferase; lesion ... See more keywords