Searching Novel Clock Genes Using RNAi-Based Screening.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0381-9_8
Abstract: RNA interference (RNAi) allows for the selective downregulation of gene expression by neutralizing targeted mRNA molecules and has frequently been used in high-throughput screening endeavors. Here, we describe a protocol for the highly parallel RNAi-mediated… read more here.
Keywords: searching novel; rnai; using rnai; novel clock ... See more keywords
Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01772
Abstract: Chromosomal region maintenance protein 1 (CRM1) is a validated anticancer drug target, and its covalent inhibitor KPT-330 has been approved for marketing. However, the development of CRM1 inhibitors, especially the noncovalent ones, is still very… read more here.
Keywords: novel noncovalent; searching novel; drug repurposing; nuclear export ... See more keywords
Searching for Novel Air Pollutants Inducers of Toxicity in the Respiratory and Immune Systems
Sign Up to like & getrecommendations! Published in 2022 at "Toxics"
DOI: 10.3390/toxics10040149
Abstract: Many contaminants may pollute the indoor or outdoor environment in a variety of ways [...]. read more here.
Keywords: air pollutants; toxicity respiratory; inducers toxicity; pollutants inducers ... See more keywords