Cell membrane permeability and defective G2/M block as factors potentially contributing to increased cell chemosensitivity. SeAx cell line as an example
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DOI: 10.1016/j.bbrep.2021.101005
Abstract: Background Immortalized mammalian cell lines are a valuable research tool, though they represent a highly simplified model. Due to accumulated mutations they may not reflect characteristics of the disease or even the tissue they derive… read more here.
Keywords: membrane permeability; block; cell membrane; seax ... See more keywords
Ruxolitinib with resminostat exert synergistic antitumor effects in Cutaneous T-cell Lymphoma
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DOI: 10.1371/journal.pone.0248298
Abstract: Background The combination of JAK/STAT and HDAC inhibitors exerted beneficial effects in haematological malignancies, presenting promising therapeutic CTCL targets. We aim to investigate the efficacy of JAK1/2i ruxolitinib in combination with HDACi resminostat in CTCL… read more here.
Keywords: ruxolitinib resminostat; combination; cell; seax ... See more keywords