Complete Inactivation of Sebum-Producing Genes Parallels the Loss of Sebaceous Glands in Cetacea
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msz068
Abstract: Abstract Genomes are dynamic biological units, with processes of gene duplication and loss triggering evolutionary novelty. The mammalian skin provides a remarkable case study on the occurrence of adaptive morphological innovations. Skin sebaceous glands (SGs),… read more here.
Keywords: sebum producing; sebaceous glands; producing genes; gene ... See more keywords
From the Cover: High Susceptibility of Lrig1 Sebaceous Stem Cells to TCDD in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfx179
Abstract: We have previously shown that cytochrome P450 1A1 (CYP1A1) was highly induced for a long period of time in a patient who had been poisoned by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a compound known to activate the aryl hydrocarbon… read more here.
Keywords: high susceptibility; cyp1a1; sebaceous glands; susceptibility lrig1 ... See more keywords
Neuroendocrinology and neurobiology of sebaceous glands
Sign Up to like & getrecommendations! Published in 2020 at "Biological Reviews"
DOI: 10.1111/brv.12579
Abstract: The nervous system communicates with peripheral tissues through nerve fibres and the systemic release of hypothalamic and pituitary neurohormones. Communication between the nervous system and the largest human organ, skin, has traditionally received little attention.… read more here.
Keywords: system; nervous system; sebum production; skin ... See more keywords
Transcriptional Differences in Lipid-Metabolizing Enzymes in Murine Sebocytes Derived from Sebaceous Glands of the Skin and Preputial Glands
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222111631
Abstract: Sebaceous glands are adnexal structures, which critically contribute to skin homeostasis and the establishment of a functional epidermal barrier. Sebocytes, the main cell population found within the sebaceous glands, are highly specialized lipid-producing cells. Sebaceous… read more here.
Keywords: preputial glands; transcriptional differences; differences lipid; lipid metabolizing ... See more keywords