Multiangle Light Scattering as a Lentivirus Purification Process Analytical Technology.
Sign Up to like & getrecommendations! Published in 2024 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c01209
Abstract: The limited biomolecular and functional stability of lentiviral vectors (LVVs) for cell therapy poses the need for analytical tools that can monitor their titers and activity throughout the various steps of expression and purification. In… read more here.
Keywords: light scattering; purification; scattering lentivirus; sec mals ... See more keywords
Polymer Characterization by Size-Exclusion Chromatography with Multi-Angle Light Scattering (SEC-MALS): A Tutorial Review.
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DOI: 10.1039/d3py01181j
Abstract: This tutorial review presents the theory and application of SEC-MALS with minimal equations and a focus on synthetic polymer characterization, serving as an entry point for polymer scientists who want to learn more about SEC-MALS.… read more here.
Keywords: polymer characterization; light scattering; tutorial review; polymer ... See more keywords
Application of Size Exclusion Chromatography with Multiangle Light Scattering in the Analytical Development of a Preclinical Stage Gene Therapy Program
Sign Up to like & getrecommendations! Published in 2023 at "Human Gene Therapy"
DOI: 10.1089/hum.2022.218
Abstract: To provide safe recombinant adeno-associated viruses (rAAV) to patients, scalable manufacturing processes are required. However, these processes may introduce impurities that impact the performance and quality of the final drug product. Empty rAAV capsids are… read more here.
Keywords: chromatography multiangle; sec mals; development; size exclusion ... See more keywords