The p24-family and COPII subunit SEC24C facilitate the clearance of alpha1-antitrypsin Z from the endoplasmic reticulum to lysosomes
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DOI: 10.1091/mbc.e23-06-0257
Abstract: A subpopulation of the alpha-1-antitrypsin misfolding Z mutant (ATZ) is cleared from the endoplasmic reticulum (ER) via an ER-to-lysosome-associated degradation (ERLAD) pathway. Here, we report that the COPII subunit SEC24C and the p24-family of proteins… read more here.
Keywords: family; p24 family; sec24c; family members ... See more keywords
SEC24C deficiency causes trafficking and glycosylation abnormalities in an epileptic encephalopathy with cataracts and dyserythropoeisis
Sign Up to like & getrecommendations! Published in 2025 at "JCI Insight"
DOI: 10.1172/jci.insight.173484
Abstract: As a major component of intracellular trafficking, the coat protein complex II (COPII) is indispensable for cellular function during embryonic development and throughout life. The 4 SEC24 proteins (A–D) are essential COPII components involved in… read more here.
Keywords: sec24c; sec24c deficiency; copii; deficiency causes ... See more keywords