Aberrant expression of Sec61α in esophageal cancers
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-02955-7
Abstract: IntroductionThe heterotrimeric Sec61α translocon complex is topological located in the membrane of the endoplasmic reticulum (ER) and allows protein transport and calcium across the membrane. Recently, aberrant expression of Sec proteins was linked to carcinogenesis… read more here.
Keywords: sec61; esophageal cancers; aberrant expression; expression sec61 ... See more keywords
Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0211180
Abstract: Proteins that misfold in the endoplasmic reticulum (ER) are transported back to the cytosol for ER-associated degradation (ERAD). The Sec61 channel is one of the candidates for the retrograde transport conduit. Channel opening from the… read more here.
Keywords: sec61; associated degradation; endoplasmic reticulum; interaction ... See more keywords
The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.788146
Abstract: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61… read more here.
Keywords: blockade; buruli ulcer; mycolactone dependent; sec61 ... See more keywords
Sec61 complex/translocon: The role of an atypical ER Ca2+-leak channel in health and disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.991149
Abstract: The heterotrimeric Sec61 protein complex forms the functional core of the so-called translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary role of the Sec61 complex is to allow protein import… read more here.
Keywords: ca2 leak; translocon; sec61; sec61 complex ... See more keywords