LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "sec61 translocon" as a keyword



Characterization of the interaction between the Sec61 translocon complex and ppαF using optical tweezers

Sign Up to like & get
recommendations! Published in 2024 at "Protein Science"

DOI: 10.1002/pro.4996

Abstract: The Sec61 translocon allows the translocation of secretory preproteins from the cytosol to the endoplasmic reticulum lumen during polypeptide biosynthesis. These proteins possess an N‐terminal signal peptide (SP) which docks at the translocon. SP mutations… read more here.

Keywords: characterization interaction; optical tweezers; sec61 translocon; translocon ... See more keywords

Protein biosynthesis at the ER: finding the right accessories

Sign Up to like & get
recommendations! Published in 2022 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e21-09-0451

Abstract: More than 30% of eukaryotic proteins contain domains that must translocate across or integrate into the endoplasmic reticulum (ER) membrane. With few exceptions, protein translocation and transmembrane domain integration at the ER require the conserved… read more here.

Keywords: biosynthesis finding; biosynthesis; accessory factors; sec61 translocon ... See more keywords

A common mechanism of Sec61 translocon inhibition by small molecules

Sign Up to like & get
recommendations! Published in 2022 at "Nature Chemical Biology"

DOI: 10.1101/2022.08.11.503542

Abstract: Itskanov and Wang et al. determined high-resolution structures of the human Sec61 channel inhibited by several structurally distinct small molecules and revealed the common inhibitor-binding site in Sec61 and molecular interactions in atomic detail. The… read more here.

Keywords: translocon inhibition; sec61 translocon; mechanism sec61; small molecules ... See more keywords

Mechanism of Protein Translocation by the Sec61 Translocon Complex.

Sign Up to like & get
recommendations! Published in 2022 at "Cold Spring Harbor perspectives in biology"

DOI: 10.1101/cshperspect.a041250

Abstract: The endoplasmic reticulum (ER) is a major site for protein synthesis, folding, and maturation in eukaryotic cells, responsible for production of secretory proteins and most integral membrane proteins. The universally conserved protein-conducting channel Sec61 complex… read more here.

Keywords: translocation sec61; sec61 translocon; protein translocation; mechanism protein ... See more keywords

Screening of gene function in cell intoxication by CNF1 links Sec61 translocon to Rac1 GTPase activity

Sign Up to like & get
recommendations! Published in 2025 at "mBio"

DOI: 10.1128/mbio.02585-24

Abstract: ABSTRACT The CNF1 toxin from extraintestinal pathogenic Escherichia coli (ExPEC) deamidates glutamine 61 of Rac1 small GTPase, as well as its equivalents in RhoA and Cdc42 into glutamic acid. This post-translational modification of Rho proteins… read more here.

Keywords: cnf1; sec61 translocon; gtpase; rac1 ... See more keywords