Protein biosynthesis at the ER: finding the right accessories
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e21-09-0451
Abstract: More than 30% of eukaryotic proteins contain domains that must translocate across or integrate into the endoplasmic reticulum (ER) membrane. With few exceptions, protein translocation and transmembrane domain integration at the ER require the conserved… read more here.
Keywords: biosynthesis finding; biosynthesis; accessory factors; sec61 translocon ... See more keywords
A common mechanism of Sec61 translocon inhibition by small molecules
Sign Up to like & getrecommendations! Published in 2022 at "Nature Chemical Biology"
DOI: 10.1101/2022.08.11.503542
Abstract: Itskanov and Wang et al. determined high-resolution structures of the human Sec61 channel inhibited by several structurally distinct small molecules and revealed the common inhibitor-binding site in Sec61 and molecular interactions in atomic detail. The… read more here.
Keywords: translocon inhibition; sec61 translocon; mechanism sec61; small molecules ... See more keywords
Mechanism of Protein Translocation by the Sec61 Translocon Complex.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a041250
Abstract: The endoplasmic reticulum (ER) is a major site for protein synthesis, folding, and maturation in eukaryotic cells, responsible for production of secretory proteins and most integral membrane proteins. The universally conserved protein-conducting channel Sec61 complex… read more here.
Keywords: translocation sec61; sec61 translocon; protein translocation; mechanism protein ... See more keywords