Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.001
Abstract: In our efforts to improve the efficacy of taxane-based microtubule (MT) stabilizing agents against tumor drug resistance mediated by multiple mechanisms, two clinically relevant factors were focused: i.e., P-glycoprotein and βIII-tubulin overexpression. Based on the… read more here.
Keywords: drug; iii tubulin; seco taxoids; modification ... See more keywords
Probing the nature of the Co(III) ion in corrins: The reactions of aquacyano-5-seco-cobyrinic acid heptamethyl ester with anionic ligands
Sign Up to like & getrecommendations! Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2018.09.073
Abstract: Abstract The substitution of H2O in aquacyano-5,6-dioxo-5,6-seco-heptamethyl-cob(III)yrinate, (aquacyano-5-seco-cobester, [AC-5-seco-Cbs]+), in which the C5–C6 bond of the corrin ring of this vitamin B12 derivative is cleaved, by a variety of anionic ligands is reported. The pKa… read more here.
Keywords: seco; anionic ligands; heptamethyl; aquacyano seco ... See more keywords
Anticancer activity of novel steroidal 6-substituted 4-en-3-one D-seco dinitriles
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2018.03.009
Abstract: HIGHLIGHTSSteroidal 6‐substituted 4‐en‐3‐one D‐seco dinitriles are synthesized.Most of the tested compounds express strong antiproliferative activity against HeLa and/or MDA‐MB‐231.Apoptosis induction in the treated MDA‐MB‐231 and HeLa cells is revealed. ABSTRACT Steroidal 16,17‐seco‐16,17a‐dinitriles possessing 4‐ene‐3,6‐dione (3),… read more here.
Keywords: seco dinitriles; mda 231; substituted one; one seco ... See more keywords