Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF Signalling
Sign Up to like & getrecommendations! Published in 2025 at "Cell Proliferation"
DOI: 10.1111/cpr.70088
Abstract: Lactate has been widely recognised as an energy source and metabolic by‐product, but increasing evidence supports its critical role as a signalling molecule or epigenetic substrate. During early embryogenesis, lactate production increases during the transition… read more here.
Keywords: pre; second cell; cell; cell fate ... See more keywords