Structural analyses of inositol phosphate second messengers bound to signaling effector proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in biological regulation"
DOI: 10.1016/j.jbior.2019.100667
Abstract: The higher-order inositol phosphate second messengers inositol tetrakisphosphate (IP4), inositol pentakisphosphate (IP5) and inositol hexakisphosphate (IP6) are important signaling molecules that regulate DNA-damage repair, cohesin dynamics, RNA-editing, retroviral assembly, nuclear transport, phosphorylation, acetylation, crotonylation, and… read more here.
Keywords: inositol; inositol phosphate; second messengers; effector proteins ... See more keywords
The ever-expanding world of bacterial cyclic oligonucleotide second messengers.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2021.01.017
Abstract: Cyclic dinucleotide (cdN) second messengers are essential for bacteria to sense and adapt to their environment. These signals were first discovered with the identification of 3'-5', 3'-5' cyclic di-GMP (c-di-GMP) in 1987, a second messenger… read more here.
Keywords: ever expanding; gmp amp; expanding world; gmp ... See more keywords
Crosstalking second messengers
Sign Up to like & getrecommendations! Published in 2021 at "Nature Microbiology"
DOI: 10.1038/s41564-020-00842-3
Abstract: By competing for the same binding site on SmbA, a regulatory nucleotide-binding protein, the bacterial second messengers c-di-GMP and (p)ppGpp inversely balance cell cycle re-entry of growth-arrested swarmer cells of Caulobacter crescentus . read more here.
Keywords: second messengers; microbiology; crosstalking second;
Nucleotide second messengers in Streptomyces.
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology"
DOI: 10.1099/mic.0.000846
Abstract: Antibiotic producing Streptomyces sense and respond to environmental signals by using nucleotide second messengers, including (p)ppGpp, cAMP, c-di-GMP and c-di-AMP. As summarized in this review, these molecules are important message carriers that coordinate the complex… read more here.
Keywords: second messengers; messengers streptomyces; microbiology; nucleotide second ... See more keywords
Network-driven intracellular cAMP coordinates circadian rhythm in the suprachiasmatic nucleus.
Sign Up to like & getrecommendations! Published in 2023 at "Science advances"
DOI: 10.1126/sciadv.abq7032
Abstract: The mammalian central circadian clock, located in the suprachiasmatic nucleus (SCN), coordinates the timing of physiology and behavior to local time cues. In the SCN, second messengers, such as cAMP and Ca2+, are suggested to… read more here.
Keywords: network; second messengers; camp; intracellular camp ... See more keywords
PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity
Sign Up to like & getrecommendations! Published in 2021 at "Theranostics"
DOI: 10.7150/thno.50701
Abstract: Synapses are the functional units of the brain. They form specific contact points that drive neuronal communication and are highly plastic in their strength, density, and shape. A carefully orchestrated balance between synaptogenesis and synaptic… read more here.
Keywords: cell types; second messengers; synaptic plasticity; cell ... See more keywords