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   Articles with "secondary amides" as a keyword



Screening for Inhibitors of Main Protease in SARS-CoV-2: In Silico and In Vitro Approach Avoiding Peptidyl Secondary Amides

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recommendations! Published in 2022 at "Journal of Chemical Information and Modeling"

DOI: 10.1021/acs.jcim.1c01087

Abstract: In addition to vaccines, antiviral drugs are essential for suppressing COVID-19. Although several inhibitor candidates were reported for SARS-CoV-2 main protease, most are highly polar peptidomimetics with poor oral bioavailability and cell membrane permeability. Here,… read more here.

Keywords: peptidyl secondary; secondary amides; sars cov; screening inhibitors ... See more keywords

Synthesis of α-Aryl Secondary Amides via Nickel-Catalyzed Reductive Coupling of Redox-Active Esters.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c00918

Abstract: The transition-metal-catalyzed α-arylation of secondary amides remains a synthetic challenge due to the presence of a free N-H bond. We report a strategy to synthesize secondary α-aryl amides via a Ni-catalyzed reductive arylation of redox-active… read more here.

Keywords: secondary amides; redox active; amides via; catalyzed reductive ... See more keywords

Selective Hydrolysis of Primary and Secondary Amides Enabled by Visible Light.

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recommendations! Published in 2023 at "Organic letters"

DOI: 10.1021/acs.orglett.3c00354

Abstract: Amide hydrolysis is a fundamentally important transformation in organic chemistry. Developing hydrolysis procedures under mild conditions with a broad substrate scope is desirable. Herein, by leveraging a photoresponsive auxiliary o-nitroanilide, we established a mild two-step… read more here.

Keywords: secondary amides; hydrolysis primary; selective hydrolysis; visible light ... See more keywords
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Enamines as Surrogates of Alkene Carbanions for the Reductive Alkenylation of Secondary Amides: An Approach to Allylamines.

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recommendations! Published in 2018 at "Organic letters"

DOI: 10.1021/acs.orglett.7b03943

Abstract: A new strategy to construct allylamines through reductive alkenylation of secondary amides with enamines is reported. The method features the use of trifluoromethanesulfonic anhydride as an activation reagent of amides, and enamines as unconventional alkenylation… read more here.

Keywords: reductive alkenylation; alkenylation secondary; secondary amides; surrogates alkene ... See more keywords

Nickel/Briphos-Catalyzed Direct Transamidation of Unactivated Secondary Amides Using Trimethylsilyl Chloride.

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recommendations! Published in 2018 at "Organic letters"

DOI: 10.1021/acs.orglett.8b03304

Abstract: Direct transamidation of secondary amides was developed via nickel catalysis. In the presence of trimethylsilyl chloride and manganese, Ni(diglyme)Cl2 with a Briphos ligand efficiently promoted the transamidation of N-aryl benzamide derivatives with primary amines to… read more here.

Keywords: nickel briphos; trimethylsilyl chloride; secondary amides; direct transamidation ... See more keywords

Nickel-Catalyzed Reductive Transamidation of Secondary Amides with Nitroarenes

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recommendations! Published in 2017 at "ACS Catalysis"

DOI: 10.1021/acscatal.7b02859

Abstract: Transmidation is an attractive method for amide synthesis. However, transamidation of secondary amides is challenging. Here, we describe a reductive transamidation method that employs readily available nitro(hetero)arenes as the nitrogen sources, zinc or manganese as… read more here.

Keywords: transamidation secondary; reductive transamidation; secondary amides; catalyzed reductive ... See more keywords

Chromium(III)-catalyzed C(sp2)-H Alkynylation, Allylation, and Naphthalenation of Secondary Amides with Trimethylaluminum as Base.

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recommendations! Published in 2020 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.0c00127

Abstract: Among base metals used for C-H activation reactions, chromium(III) is rather unexplored despite its natural abundance and low toxicity. We report herein chromium(III)-catalyzed C(sp2)-H functionalization of an ortho-position of aromatic and α,β-unsaturated secondary amides using… read more here.

Keywords: iii; catalyzed sp2; secondary amides; iii catalyzed ... See more keywords

Multicatalysis protocol enables direct and versatile enantioselective reductive transformations of secondary amides

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.ade3431

Abstract: The catalytic asymmetric geminal bis-nucleophilic addition to nonreactive functional groups is a type of highly desirable yet challenging transformation in organic chemistry. Here, we report the first catalytic asymmetric reductive/deoxygenative alkynylation of secondary amides. The… read more here.

Keywords: secondary amides; multicatalysis protocol; enantioselective reductive; protocol ... See more keywords