Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.10.003
Abstract: Clostridium scindens biotransforms primary bile acids into secondary bile acids, and is correlated with inhibition of Clostridium difficile growth in vivo. The aim of the current study was to determine how C. scindens regulates C. difficile growth in vitro… read more here.
Keywords: clostridium difficile; bile acids; acid dehydroxylating; secondary bile ... See more keywords
Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102036
Abstract: Summary Bile acids are metabolites of cholesterol that facilitate lipid digestion and absorption in the small bowel. Bile acids work as agonists of receptors to regulate their own metabolism. Bile acids also regulate other biological… read more here.
Keywords: bile; bile acids; human serine; secondary bile ... See more keywords
Developmental stages in microbiota, bile acids, and clostridial species in healthy puppies
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DOI: 10.1111/jvim.15928
Abstract: Abstract Background The fecal microbiota, fecal bile acid concentrations, and abundance of Clostridium perfringens and Clostridium difficile are altered in acute and chronic gastrointestinal disease in adult dogs. However, less is known in young puppies.… read more here.
Keywords: clostridial species; bile acids; healthy puppies; adult dogs ... See more keywords
Research on Gut Microbiota-Derived Secondary Bile Acids in Cancer Progression
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DOI: 10.1177/15347354221114100
Abstract: The interaction between gut microbiota-derived metabolites and the body plays a significant role in the occurrence and development of cancer. Secondary bile acids (BAs) are the important products produced from gut microbial fermentation of primary… read more here.
Keywords: gut; gut microbiota; secondary bile; bile acids ... See more keywords
The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis
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DOI: 10.14814/phy2.14456
Abstract: Increased epithelial permeability is a key feature of IBD pathogenesis and it has been proposed that agents which promote barrier function may be of therapeutic benefit. We have previously reported the secondary bile acid, ursodeoxycholic… read more here.
Keywords: bile acids; colonic inflammation; ursodeoxycholic acid; apoptosis ... See more keywords
Disease-Associated Gut Microbiota Reduces the Profile of Secondary Bile Acids in Pediatric Nonalcoholic Fatty Liver Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.698852
Abstract: Children with nonalcoholic fatty liver disease (NAFLD) display an altered gut microbiota compared with healthy children. However, little is known about the fecal bile acid profiles and their association with gut microbiota dysbiosis in pediatric… read more here.
Keywords: secondary bile; bile acids; gut microbiota; disease ... See more keywords
Patients with Primary and Secondary Bile Duct Stones Harbor Distinct Biliary Microbial Composition and Metabolic Potential
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DOI: 10.3389/fcimb.2022.881489
Abstract: Introduction Cholelithiasis has a high incidence worldwide and limited treatment options due to its poorly understood pathogenesis. Furthermore, the role of biliary microbiota in cholelithiasis remains understudied. To address these questions, we performed microbial sequencing… read more here.
Keywords: secondary bile; pbds; cholelithiasis; bile duct ... See more keywords
Secondary Bile Acids and Tumorigenesis in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.813745
Abstract: Colorectal cancer (CRC) is one of the most common and deadly cancers in the world and is a typical inflammatory tumor. In recent years, the incidence of CRC has been increasing year by year. There… read more here.
Keywords: secondary bile; crc; bile acids; colorectal cancer ... See more keywords
Glucosylceramide Changes Bacterial Metabolism and Increases Gram-Positive Bacteria through Tolerance to Secondary Bile Acids In Vitro
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DOI: 10.3390/ijms23105300
Abstract: Glucosylceramide is present in many foods, such as crops and fermented foods. Most glucosylceramides are not degraded or absorbed in the small intestine and pass through the large intestine. Glucosylceramide exerts versatile effects on colon… read more here.
Keywords: metabolism; intestinal microbes; secondary bile; tolerance secondary ... See more keywords
Infants Fed Breastmilk or 2′-FL Supplemented Formula Have Similar Systemic Levels of Microbiota-Derived Secondary Bile Acids
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DOI: 10.3390/nu15102339
Abstract: Human milk represents an optimal source of nutrition during infancy. Milk also serves as a vehicle for the transfer of growth factors, commensal microbes, and prebiotic compounds to the immature gastrointestinal tract. These immunomodulatory and… read more here.
Keywords: secondary bile; supplemented formula; formula; infant formula ... See more keywords
Secondary bile acids and the biliary epithelia: The good and the bad
Sign Up to like & getrecommendations! Published in 2023 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v29.i2.357
Abstract: The biliary tract has been considered for several decades a passive system just leading the hepatic bile to the intestine. Nowadays several researches demonstrated an important role of biliary epithelia (i.e. cholangiocytes) in bile formation.… read more here.
Keywords: bas; secondary bile; biliary epithelia; bile acids ... See more keywords