In Situ Proliferating Peptide Nanoparticle Augments Multi‐Target Intervention of Secondary Brain Damage Following Subarachnoid Hemorrhage
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DOI: 10.1002/advs.202417456
Abstract: Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered by neuro‐glial units for persistent neuroinflammation, oxidative damage and programmed neuronal cell death. Single‐target and traditional multi‐target therapies, derived from individual drugs, show… read more here.
Keywords: damage; secondary brain; subarachnoid hemorrhage; multi target ... See more keywords
Acrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice
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DOI: 10.1007/s12264-020-00505-7
Abstract: Clinical advances in the treatment of intracranial hemorrhage (ICH) are restricted by the incomplete understanding of the molecular mechanisms contributing to secondary brain injury. Acrolein is a highly active unsaturated aldehyde which has been implicated… read more here.
Keywords: secondary brain; brain; damage; brain injury ... See more keywords
Circulatory dipeptidyl peptidase 3 (cDPP3) is a potential biomarker for early detection of secondary brain injury after aneurysmal subarachnoid hemorrhage
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2021.117333
Abstract: INTRODUCTION Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) that can culminate in secondary brain damage. Although it remains one of the main preventable causes of aSAH-related morbidity, there is… read more here.
Keywords: aneurysmal subarachnoid; secondary brain; subarachnoid hemorrhage; cdpp3 levels ... See more keywords
Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage
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DOI: 10.1016/j.pneurobio.2019.03.003
Abstract: Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic treatment for ICH and benefit poorly from this regimen. Inflammatory cytokines are… read more here.
Keywords: cytokines secondary; secondary brain; intracerebral hemorrhage; inflammatory cytokines ... See more keywords
A bioimpedance-based monitor for real-time detection and identification of secondary brain injury
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DOI: 10.1038/s41598-021-94600-y
Abstract: Secondary brain injury impacts patient prognosis and can lead to long-term morbidity and mortality in cases of trauma. Continuous monitoring of secondary injury in acute clinical settings is primarily limited to intracranial pressure (ICP); however,… read more here.
Keywords: secondary brain; monitor; bioimpedance; brain injury ... See more keywords
Use of drugs for hyperlipidaemia and diabetes and risk of primary and secondary brain tumours: nested case–control studies using the UK Clinical Practice Research Datalink (CPRD)
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DOI: 10.1136/bmjopen-2023-072026
Abstract: Objectives Previous studies have suggested that fibrates and glitazones may have a role in brain tumour prevention. We examined if there is support for these observations using primary care records from the UK Clinical Practice… read more here.
Keywords: brain; brain tumours; primary secondary; secondary brain ... See more keywords
Direct Oral Anticoagulants (DOACs) Vs. Low Molecular Weight Heparins (LMWH) for Venous Thromboembolism (VTE) in Patients with Primary Brain Tumors or Secondary Brain Metastases
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DOI: 10.1182/blood-2020-138635
Abstract: Background: Management of venous thromboembolism (VTE) in patients with central nervous system (CNS) malignancies is challenging as there is an increased risk of recurrent VTE and intracranial hemorrhage (ICH). Low molecular weight heparins (LMWH) have… read more here.
Keywords: vte; primary brain; patients primary; secondary brain ... See more keywords
C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury
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DOI: 10.1186/s12987-024-00594-w
Abstract: Preclinical studies indicate that the systemic application of C1-inhibitor, clinically used to treat hereditary angioedema, reduces secondary brain injury after ischemic stroke. This study assessed the effect of C1-inhibitor on secondary brain injury after hemorrhagic… read more here.
Keywords: intracerebral hemorrhage; brain injury; secondary brain;
Mitochondria: Novel Mechanisms and Therapeutic Targets for Secondary Brain Injury After Intracerebral Hemorrhage
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DOI: 10.3389/fnagi.2020.615451
Abstract: Intracerebral hemorrhage (ICH) is a destructive form of stroke that often results in death or disability. However, the survivors usually experience sequelae of neurological impairments and psychiatric disorders, which affect their daily functionality and working… read more here.
Keywords: intracerebral hemorrhage; secondary brain; brain; brain injury ... See more keywords
Secondary Brain Injury by Oxidative Stress After Cerebral Hemorrhage: Recent Advances
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DOI: 10.3389/fncel.2022.853589
Abstract: Intracerebral hemorrhage (ICH) is a clinical syndrome in which blood accumulates in the brain parenchyma because of a nontraumatic rupture of a blood vessel. Because of its high morbidity and mortality rate and the lack… read more here.
Keywords: stress; hemorrhage; secondary brain; oxidative stress ... See more keywords
Gap Junctions and Hemichannels Composed of Connexins and Pannexins Mediate the Secondary Brain Injury Following Intracerebral Hemorrhage
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DOI: 10.3390/biology11010027
Abstract: Simple Summary Intracerebral hemorrhage (ICH) is a leading medical problem without effective treatment options. The poor prognosis is attributed to the primary brain injury of the mechanical compression caused by hematoma, and secondary brain injury… read more here.
Keywords: brain injury; junctions hemichannels; secondary brain; gap junctions ... See more keywords