A Novel Targeted Nanoparticle for Traumatic Brain Injury Treatment: Combined Effect of ROS Depletion and Calcium Overload Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202102256
Abstract: Survival after severe traumatic brain injury (TBI) depends on minimizing or avoiding secondary insults to the brain. Overproduction of reactive oxygen species (ROS) and Ca2+ influx at the damaged site are the key factors that… read more here.
Keywords: traumatic brain; tbi; brain; brain injury ... See more keywords
Berberine Protects Secondary Injury in Mice with Traumatic Brain Injury Through Anti-oxidative and Anti-inflammatory Modulation
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2597-5
Abstract: Traumatic brain injury (TBI) is one of the major causes of death and disability worldwide. Novel and effective therapy is needed to prevent the secondary spread of damage beyond the initial injury. The aim of… read more here.
Keywords: traumatic brain; secondary injury; tbi; injury ... See more keywords
The mechanism of Zhenzhu Pills treating intracerebral hemorrhage secondary injury based on network pharmacology and molecular docking
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DOI: 10.1097/md.0000000000036837
Abstract: Background: Intracerebral hemorrhage (ICH) secondary injury is serious and affects patient’s prognosis. The Zhenzhu Pills used to treat subacute ICH in Tibet has shown to have a certain curative effect. Network pharmacology and molecular docking… read more here.
Keywords: molecular docking; pharmacology; medicine; secondary injury ... See more keywords
Perampanel for alleviation of secondary injury in traumatic brain injury (PEACE-TBI): a protocol for a phase-II multicentre randomised clinical trial
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DOI: 10.1136/bmjopen-2025-105190
Abstract: Introduction Traumatic brain injury (TBI) often causes permanent neurological dysfunction. Although no medication has been validated yet to prevent secondary injury of brain tissue, recent animal studies have reported that perampanel, a glutamine receptor antagonist,… read more here.
Keywords: traumatic brain; trial; injury; tbi ... See more keywords
Astrocyte-targeted Overproduction of IL-10 Reduces Neurodegeneration after TBI
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DOI: 10.5607/en21035
Abstract: Traumatic brain injury is the greatest cause of disability and death in young adults in the developed world. The outcome for a TBI patient is determined by the severity of the injury, not only from… read more here.
Keywords: astrocyte targeted; tbi; production; secondary injury ... See more keywords