Secondary Metabolic Potential of Kutzneria.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.3c00007
Abstract: Kutzneria is a rare genus of Actinobacteria that harbors a variety of secondary metabolite gene clusters and produces several interesting types of bioactive secondary metabolites. Recent efforts have partially elucidated the biosynthetic pathways of some… read more here.
Keywords: kutzneria; metabolic potential; natural products; metabolic enzymes ... See more keywords
Metabologenomics analysis reveals antibiotic crypticity of Kutzneria viridogrisea DSM 43850.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of applied microbiology"
DOI: 10.1093/jambio/lxaf114
Abstract: AIMS This study aimed to explore the secondary metabolic potential of Kutzneria viridogrisea DSM 43850 by conducting whole-genome sequencing and utilizing bioinformatics tools to analyze its biosynthetic gene clusters (BGCs). Additionally, the secondary metabolites produced… read more here.
Keywords: secondary metabolic; analysis; dsm 43850; viridogrisea dsm ... See more keywords
A Secondary Metabolic Enzyme Functioned as an Evolutionary Seed of a Primary Metabolic Enzyme
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac164
Abstract: Abstract The antibiotic alaremycin has a structure that resembles that of 5-aminolevulinic acid (ALA), a universal precursor of porphyrins, and inhibits porphyrin biosynthesis. Genome sequencing of the alaremycin-producing bacterial strain and enzymatic analysis revealed that… read more here.
Keywords: evolutionary seed; secondary metabolic; enzyme; seed ... See more keywords
Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways
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DOI: 10.1128/spectrum.00898-21
Abstract: There is an urgent need for novel bioactive molecules in both agriculture and medicine. The genomes of fungi are thought to contain vast numbers of metabolic pathways involved in the biosynthesis of secondary metabolites with… read more here.
Keywords: secondary metabolic; transcription; gene; genome wide ... See more keywords
Integrated omics unveil the secondary metabolic landscape of a basal dinoflagellate
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DOI: 10.1186/s12915-020-00873-6
Abstract: Background Some dinoflagellates cause harmful algal blooms, releasing toxic secondary metabolites, to the detriment of marine ecosystems and human health. Our understanding of dinoflagellate toxin biosynthesis has been hampered by their unusually large genomes. To… read more here.
Keywords: basal dinoflagellate; omics unveil; unveil secondary; dinoflagellate ... See more keywords
Multifunctional Enzymes in Microbial Secondary Metabolic Processes
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DOI: 10.3390/catal13030581
Abstract: Microorganisms possess a strong capacity for secondary metabolite synthesis, which is represented by tightly controlled networks. The absence of any enzymes leads to a change in the original metabolic pathway, with a decrease in or… read more here.
Keywords: enzymes microbial; metabolic processes; multifunctional enzymes; secondary metabolic ... See more keywords
Potential of Anti-Cancer Activity of Secondary Metabolic Products from Marine Fungi
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Fungi"
DOI: 10.3390/jof7060436
Abstract: The promising feature of the fungi from the marine environment as a source for anticancer agents belongs to the fungal ability to produce several compounds and enzymes which contribute effectively against the cancer cells growth.… read more here.
Keywords: fungi potential; secondary metabolic; cancer cells; cancer ... See more keywords