Draft genome and secondary metabolite biosynthetic gene clusters of Streptomyces sp. strain 196.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05731-w
Abstract: Emergence of MDR 'superbugs' inflamed a severe sense of urgency amongst scientists aiming at the discovery of novel potential drug molecules. Bacteria of the genus Streptomyces are really worth investigating for their immense potential to… read more here.
Keywords: secondary metabolite; streptomyces strain; strain 196; gene clusters ... See more keywords
Cofactor recycling strategies for secondary metabolite production in cell-free protein expression systems
Sign Up to like & getrecommendations! Published in 2024 at "Biophysical Reviews"
DOI: 10.1007/s12551-024-01234-1
Abstract: Cell-free protein synthesis (CFPS) has emerged as an attractive platform for biotechnology and synthetic biology due to its numerous advantages to cell-based technologies for specific applications. CFPS can be faster, less sensitive to metabolite toxicity,… read more here.
Keywords: metabolite production; cell free; secondary metabolite; cofactor recycling ... See more keywords
CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.08.009
Abstract: With the advent of genome sequencing and mining technologies, secondary metabolite biosynthetic gene clusters (BGCs) within bacterial genomes are becoming easier to predict. For subsequent BGC characterization, clustered regularly interspaced short palindromic repeats (CRISPR) has… read more here.
Keywords: crage; secondary metabolite; crage crispr; biosynthetic gene ... See more keywords
Characterization of the secondary metabolite biosynthetic gene clusters in archaea
Sign Up to like & getrecommendations! Published in 2019 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.11.019
Abstract: Secondary metabolites are a range of bioactive compounds yielded by bacteria, fungi and plants, etc. The published archaea genomic data provide the opportunity for efficient identification of secondary metabolite biosynthetic gene clusters (BGCs) by genome… read more here.
Keywords: biosynthetic gene; gene clusters; secondary metabolite; metabolite biosynthetic ... See more keywords
Untangling the UV-B radiation-induced transcriptional network regulating plant morphogenesis and secondary metabolite production
Sign Up to like & getrecommendations! Published in 2021 at "Environmental and Experimental Botany"
DOI: 10.1016/j.envexpbot.2021.104655
Abstract: Abstract Earlier, Ultraviolet-B (UV-B) radiations were considered to be detrimental to plant cells and their components. But recent researches have shown that it has multifaceted impacts on plants. The discovery of UV-B RESISTANCE 8 (UVR8)… read more here.
Keywords: plant morphogenesis; metabolite production; secondary metabolite; plant ... See more keywords
Secondary metabolite profiles of small-spored Alternaria support the new phylogenetic organization of the genus.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of food microbiology"
DOI: 10.1016/j.ijfoodmicro.2018.11.022
Abstract: The group of the small-spored Alternaria species is particularly relevant in foods due to its high frequency and wide distribution in different crops. These species are responsible for the accumulation of mycotoxins and bioactive secondary… read more here.
Keywords: small spored; secondary metabolite; spored alternaria; metabolite ... See more keywords
Modulation of secondary metabolite profiles by biologically synthesized MgO/perlite nanocomposites in Melissa officinalis plant organ cultures.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2019.120878
Abstract: In this work, biological synthesis of MgO/perlite nanocomposites (NCs) besides their effects on morphology and secondary metabolite profiles of Melissa officinalis plant organ cultures were evaluated. MgO NPs were immobilized on the surface of nanoperlite… read more here.
Keywords: mgo; secondary metabolite; perlite ncs; mgo perlite ... See more keywords
laeA Gene Introduction Strategy Enabling the Construction of a Prolific Fungal Secondary Metabolite Library.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.4c01317
Abstract: LaeA is a putative nuclear methyltransferase protein that epigenetically influences secondary metabolite production in fungi. LaeA has drawn attention as one of the promising approaches to activate fungal chemical production, and the laeA gene has… read more here.
Keywords: introduction strategy; strategy enabling; laea gene; secondary metabolite ... See more keywords
Genomic Locus of a Penicillium crustosum Pigment as an Integration Site for Secondary Metabolite Gene Expression.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00164
Abstract: Heterologous expression of secondary metabolite genes and gene clusters has been proven to be a successful strategy for identification of new natural products of cryptic or silent genes hidden in the genome sequences. It is… read more here.
Keywords: crustosum; secondary metabolite; integration; expression ... See more keywords
Vitamin B3 Triggers Biosynthesis of Secondary Metabolite Dormancy Signals in Streptococcus suis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c05790
Abstract: Human-associated streptococci have not been viewed as productive sources of natural products. Against expectation, bioinformatic searches recently revealed a large collection of diverse biosynthetic gene clusters coding for ribosomally synthesized and post-translationally modified peptides (RiPPs)… read more here.
Keywords: metabolite dormancy; triggers biosynthesis; secondary metabolite; biosynthesis secondary ... See more keywords
Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0207-y
Abstract: In soil ecosystems, microorganisms produce diverse secondary metabolites such as antibiotics, antifungals and siderophores that mediate communication, competition and interactions with other organisms and the environment1,2. Most known antibiotics are derived from a few culturable… read more here.
Keywords: secondary metabolite; metabolite biosynthesis; nonribosomal peptide; soil ... See more keywords