Elasticity-Associated Functionality and Inhibition of the HIV Protease.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2021_655
Abstract: HIV protease plays a critical role in the life cycle of the virus through the generation of mature and infectious virions. Detailed knowledge of the structure of the enzyme and its substrate has led to… read more here.
Keywords: elasticity; protease; inhibition; drug ... See more keywords
Discovery of a Potent FLT3 Inhibitor (LT-850-166) with the Capacity of Overcoming a Variety of FLT3 Mutations.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01196
Abstract: Secondary mutations of FLT3 have become the main mechanism of FLT3 inhibitor resistance that presents a significant clinical challenge. Herein, a series of pyrazole-3-amine derivatives were synthesized and optimized to overcome the common secondary resistance… read more here.
Keywords: flt3 inhibitor; discovery potent; variety; flt3 ... See more keywords
Modulating Mistranslation Potential of tRNASer in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302525
Abstract: Mistranslation, incorporating an amino acid not specified by the "standard" genetic code, has applications in research and synthetic biology. Since mistranslation is toxic, its level must be modulated. Using a serine tRNA with a proline… read more here.
Keywords: mistranslation potential; potential trnaser; biology; mistranslation ... See more keywords