Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis
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DOI: 10.1007/s00018-021-04078-0
Abstract: Secondary necrosis has long been perceived as an uncontrolled process resulting in total lysis of the apoptotic cell. Recently, it was shown that progression of apoptosis to secondary necrosis is regulated by Gasdermin E (GSDME),… read more here.
Keywords: necrosis; apoptosis; plasma membrane; secondary necrosis ... See more keywords
The deafness gene GSDME: its involvement in cell apoptosis, secondary necrosis, and cancers
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DOI: 10.1007/s00210-019-01674-7
Abstract: Gasdermin E (GSDME), also called DFNA5, is a member of the gasdermin family. GSDME is involved in the regulation of apoptosis and necrosis. The N-terminal domain of GSDME displays an apoptosis-inducing activity while the C-terminal… read more here.
Keywords: necrosis; deafness gene; apoptosis; gsdme ... See more keywords
ABT-737 Triggers Caspase-Dependent Inhibition of Platelet Procoagulant Extracellular Vesicle Release during Apoptosis and Secondary Necrosis In Vitro
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DOI: 10.1055/s-0039-1693694
Abstract: Platelet lifespan is limited by activation of intrinsic apoptosis. Apoptotic platelets are rapidly cleared from the circulation in vivo. ABT-737 triggers platelet apoptosis and is a useful tool for studying this process. However, in vitro… read more here.
Keywords: apoptotic platelets; apoptosis; abt 737; secondary necrosis ... See more keywords
Caspase‐3‐mediated GSDME activation contributes to cisplatin‐ and doxorubicin‐induced secondary necrosis in mouse macrophages
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DOI: 10.1111/cpr.12663
Abstract: Induction of secondary necrosis/pyroptosis contributes to the toxicity of chemotherapeutic drugs, in which gasdermin E (GSDME) plays critical roles. This study aimed to explore whether GSDME is involved in mediating the cytotoxic effects of cisplatin… read more here.
Keywords: caspase mediated; mouse macrophages; cisplatin doxorubicin; secondary necrosis ... See more keywords