A Competition of Secondary and Primary Nucleation Controls Amyloid Fibril Formation of the Parathyroid Hormone.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200525
Abstract: Functional amyloids belong to an increasing class of non-toxic biologic material, in contrast to the prominent disease-related amyloids. Here, we report on the fibril formation of the parathyroid hormone PTH84 as a representative candidate following… read more here.
Keywords: nucleation; formation parathyroid; secondary nucleation; parathyroid hormone ... See more keywords
Stabilization of the cellular structure of polypropylene foams and secondary nucleation mechanism in the presence of graphene nanoplatelets
Sign Up to like & getrecommendations! Published in 2020 at "Polymer"
DOI: 10.1016/j.polymer.2020.122506
Abstract: Abstract Graphene nanoplatelets (GNPs) consisting of few-layered graphene (FLG) with surface area of about 400 g/cm2 were prepared from expanded graphite (EG) using a shear-induced thermomechanical exfoliation process. Melt compounded composites of EG with polypropylene (PP)… read more here.
Keywords: secondary nucleation; presence; nucleation; cellular structure ... See more keywords
Morphology of discontinuous metal films with pronounced secondary nucleation
Sign Up to like & getrecommendations! Published in 2019 at "Vacuum"
DOI: 10.1016/j.vacuum.2019.01.035
Abstract: Abstract Computer experimental methods are used to study the initial stages of growth of metallic layers on a dielectric substrate. The main focus of attention is the growth phases of the metallic layers in which… read more here.
Keywords: discontinuous metal; nucleation; morphology discontinuous; secondary nucleation ... See more keywords
Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00003
Abstract: Protein oligomerization is a commonly encountered strategy by which the functional repertoire of proteins is increased. This, however, is a double-edged sword strategy because protein oligomerization is notoriously difficult to control. Living organisms have therefore… read more here.
Keywords: secondary nucleation; prosp brichos; nucleation; spectroscopy ... See more keywords
Role of Hydrophobicity at the N-Terminal Region of Aβ42 in Secondary Nucleation
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00504
Abstract: The self-assembly of the amyloid β 42 (Aβ42) peptide is linked to Alzheimer’s disease, and oligomeric intermediates are linked to neuronal cell death during the pathology of the disease. These oligomers are produced prolifically during… read more here.
Keywords: region secondary; nucleation; hydrophobicity; terminal region ... See more keywords
Secondary Nucleation-Triggered Physical Cross-Links and Tunable Stiffness in Seeded Supramolecular Hydrogels.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03230
Abstract: Mechanistic understanding and the control of molecular self-assembly at all hierarchical levels remain grand challenges in supramolecular chemistry. Functional realization of dynamic supramolecular materials especially requires programmed assembly at higher levels of molecular organization. Herein,… read more here.
Keywords: topology; cross links; secondary nucleation; supramolecular hydrogels ... See more keywords
Fine-tuning of the size of supramolecular nanotoroids suppresses the subsequent catenation of nano-[2]catenane
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc07063d
Abstract: A judicious combination of ring-closing supramolecular polymerization and secondary nucleation can hierarchically organize a diphenylnaphthalene barbiturate monomer bearing a 3,4,5-tri(dodecyloxy)benzyloxy unit into self-assembled nano-polycatenanes composed of nanotoroids. In our previous study, nano-polycatenanes of variable length… read more here.
Keywords: size supramolecular; nano; nano catenane; tuning size ... See more keywords
Distinct seed topologies enable comparison of elongation and secondary nucleation pathways in seeded supramolecular polymerization.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01587d
Abstract: The influence of seed topologies on seeded supramolecular polymerization was examined using helicoidal and toroidal supramolecular polymer seeds. The addition of these seeds to a supersaturated solution of monomers led to distinct nucleation-growth kinetics, which… read more here.
Keywords: supramolecular polymerization; seeded supramolecular; nucleation; seed topologies ... See more keywords
Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1918481117
Abstract: Significance Two unresolved problems in Alzheimer’s disease (AD) are its onset and propagation, linked to Aβ peptide aggregation. Fibrils of Aβ42 may grow by monomer addition at their ends. Additionally, through so-called secondary nucleation, fibrils… read more here.
Keywords: secondary nucleation; self replication; alzheimer associated; sides fibrils ... See more keywords
Membrane-Catalyzed Aggregation of Islet Amyloid Polypeptide Is Dominated by Secondary Nucleation
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1101/2022.02.04.479144
Abstract: Type II diabetes is characterized by the loss of pancreatic β-cells. This loss is thought to be a consequence of membrane disruption, caused by the aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils. However,… read more here.
Keywords: aggregation; aggregation islet; secondary nucleation; membrane ... See more keywords
Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β40 (Aβ40) by the peptide fragment Aβ16–22
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav8216
Abstract: Combined experiment and simulation reveals a structural mechanism of surface-catalyzed nucleation in Aβ amyloid formation. Understanding the structural mechanism by which proteins and peptides aggregate is crucial, given the role of fibrillar aggregates in debilitating… read more here.
Keywords: surface catalyzed; secondary nucleation; amyloid; nucleation ... See more keywords