Peptidic Scaffolds Enable Rapid and Multivariate Secondary Sphere Evolution for an Abiotic Metallocatalyst.
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DOI: 10.1021/acs.inorgchem.2c00901
Abstract: Metalloenzymes have benefited from the iterative process of evolution to achieve the precise arrangements of secondary sphere non-covalent interactions that enhance metal-centered catalysis. Iterative synthesis of scaffolds that display complex secondary sphere elements in abiotic… read more here.
Keywords: scaffolds enable; rapid multivariate; secondary sphere; peptidic scaffolds ... See more keywords
The Power of the Secondary Sphere: Modulating Hydrogenase Activity in Nickel-Substituted Rubredoxin
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DOI: 10.2210/pdb6nw1/pdb
Abstract: Secondary sphere interactions are known to significantly impact catalytic rates within biological systems as well as synthetic molecular catalysts. The [NiFe] hydrogenase enzymes oxidize and produc... read more here.
Keywords: hydrogenase activity; secondary sphere; power secondary; hydrogenase ... See more keywords