A GH Secretagogue Receptor Agonist (LUM-201) Elicits Greater GH Responses than Standard GH Secretagogues in Subjects of a Pediatric GH Deficiency Trial
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DOI: 10.1159/000524244
Abstract: Introduction: LUM-201 (ibutamoren, formerly MK-0677) is an orally administered GH secretagogue receptor agonist under development for treatment of pediatric growth hormone deficiency (PGHD). Methods: The GH response to a single dose of LUM-201 and to… read more here.
Keywords: lum 201; responses standard; greater responses; secretagogue receptor ... See more keywords
Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity
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DOI: 10.3390/biom12101370
Abstract: The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC). We have shown 17β-estradiol (E2) increases Ghsr expression… read more here.
Keywords: ghsr; ghrelin; growth hormone; secretagogue receptor ... See more keywords
Establishment of a Cell Line Stably Expressing the Growth Hormone Secretagogue Receptor to Identify Crocin as a Ghrelin Agonist
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DOI: 10.3390/biom12121813
Abstract: The growth hormone secretagogue receptor-1a (GHSR1a) is the endogenous receptor for ghrelin. Activation of GHSR1a participates in many physiological processes including energy homeostasis and eating behavior. Due to its transitory half-life, the efficacy of ghrelin… read more here.
Keywords: ghsr1a; cell; growth hormone; secretagogue receptor ... See more keywords