Intramembranous processing by γ‐secretase regulates reverse signaling of ephrin‐B2 in migration of microglia
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23147
Abstract: The Eph‐ephrin system plays pivotal roles in cell adhesion and migration. The receptor‐like functions of the ephrin ligands allow the regulation of intracellular processes via reverse signaling. γ‐Secretase mediated processing of ephrin‐B has previously been… read more here.
Keywords: intramembranous processing; secretase regulates; migration; processing secretase ... See more keywords
γ‐Secretase Inhibition Induces Muscle Hypertrophy in a Notch‐Independent Mechanism
Sign Up to like & getrecommendations! Published in 2018 at "PROTEOMICS"
DOI: 10.1002/pmic.201700423
Abstract: A wide variety of cellular processes and signaling events are regulated by the proteolytic enzyme γ‐secretase. Notch‐1 is one of the substrates of γ‐secretase and its role in the regulation of muscle differentiation has been… read more here.
Keywords: secretase; induces muscle; muscle hypertrophy; secretase inhibition ... See more keywords
Substrate-based chemical probes for Alzheimer’s γ-secretase
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02565-w
Abstract: The membrane-embedded γ-secretase complex carries out hydrolysis within the lipid bilayer in proteolyzing nearly 100 different membrane protein substrates. Among these substrates, the amyloid precursor protein (APP) has been the most studied, as generation of… read more here.
Keywords: secretase; based chemical; substrate based; chemical probes ... See more keywords
Dysfunctional γ-Secretase in Familial Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2511-1
Abstract: Genetics strongly implicate the amyloid β-peptide (Aβ) in the pathogenesis of Alzheimer’s disease. Dominant missense mutation in the presenilins and the amyloid precursor protein (APP) cause early-onset familial Alzheimer’s disease (FAD). As presenilin is the… read more here.
Keywords: alzheimer disease; familial alzheimer; secretase; dysfunctional secretase ... See more keywords
Inhibition of γ-Secretase Leads to an Increase in Presenilin-1
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0705-1
Abstract: Abstractγ-Secretase inhibitors (GSIs) are potential therapeutic agents for Alzheimer’s disease (AD); however, trials have proven disappointing. We addressed the possibility that γ-secretase inhibition can provoke a rebound effect, elevating the levels of the catalytic γ-secretase… read more here.
Keywords: ps1; secretase leads; inhibition; increase ... See more keywords
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.092
Abstract: Dysregulation of the Amyloid Precursor Protein (APP) processing leading to toxic species of amyloid β peptides (Aβ) is central to Alzheimer's disease (AD) etiology. Aβ peptides are produced by sequential cleavage of APP by β-secretase… read more here.
Keywords: precursor protein; indirect secretase; profile indirect; new profile ... See more keywords
Small molecules targeting γ-secretase and their potential biological applications.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114169
Abstract: The γ-secretase is a large transmembrane protein complex composed of four distinct units. It has aroused numerous attention over the past two decades as its intriguing role in mediating intramembrane proteolysis. γ-Secretase controls the cleavage… read more here.
Keywords: molecules targeting; potential biological; small molecules; secretase ... See more keywords
Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization
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DOI: 10.1016/j.isci.2020.101887
Abstract: Summary Amyloid precursor protein (APP) cleavage by the β-secretase produces the C99 transmembrane (TM) protein, which contains three dimerization-inducing Gly-x-x-x-Gly motifs. We demonstrate that dimeric C99 TM orientations regulate the precise cleavage lines by γ-secretase.… read more here.
Keywords: dimeric transmembrane; secretase; processing; processing line ... See more keywords
Beta-secretase/BACE1 promotes APP endocytosis and processing in the endosomes and on cell membrane
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.08.016
Abstract: Amyloid-β proteins deposition and aggregation occur in extracellular space and form neuritic plaques in Alzheimer's disease (AD) brain. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1)/ β-secretase and γ-secretase Presenilin 1 (PSEN1) conduct sequential cleavage… read more here.
Keywords: processing; cell membrane; endocytosis; secretase ... See more keywords
Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.09.001
Abstract: Hyperinsulinemia activates brain Akt and PKC-λ/ι and increases Aβ1-40/42 and phospho-tau in insulin-resistant animals. Here, we examined underlying mechanisms in mice, neuronal cells, and mouse hippocampal slices. Like Aβ1-40/42, β-secretase activity was increased in insulin-resistant… read more here.
Keywords: neuronal cells; hyperinsulinemia; pkc; brain ... See more keywords
ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2021.102032
Abstract: ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-β (Aβ) metabolism, is a major genetic risk determinant for Alzheimer's Disease (AD) and drives its pathogenesis via Aβ-dependent and -independent pathways. C/EBPβ, a proinflammatory cytokines-activated transcription… read more here.
Keywords: alzheimer disease; pathogenesis; apoe4; ebp secretase ... See more keywords